发明公开
EP2404896A1 CYCLOHEXANE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISM
审中-公开
CYCLOHEXANDERIVAT MIT NPY-Y5-REZEPTORANTAGONISMUS
- 专利标题: CYCLOHEXANE DERIVATIVE HAVING NPY Y5 RECEPTOR ANTAGONISM
- 专利标题(中): CYCLOHEXANDERIVAT MIT NPY-Y5-REZEPTORANTAGONISMUS
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申请号: EP10748840.5申请日: 2010-03-05
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公开(公告)号: EP2404896A1公开(公告)日: 2012-01-11
- 发明人: YOSHIDA, Hiroshi , TONOGAKI, Keisuke , SAKAGAMI, Masahiro , TAKAYA, Kenji
- 申请人: Shionogi & Co., Ltd.
- 申请人地址: 1-8, Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541-0045 JP
- 专利权人: Shionogi & Co., Ltd.
- 当前专利权人: Shionogi & Co., Ltd.
- 当前专利权人地址: 1-8, Doshomachi 3-chome Chuo-ku Osaka-shi Osaka 541-0045 JP
- 代理机构: HOFFMANN EITLE
- 优先权: JP2009052065 20090305
- 国际公布: WO2010101247 20100910
- 主分类号: C07C237/24
- IPC分类号: C07C237/24 ; A61K31/167 ; A61K31/275 ; A61K31/415 ; A61K31/4184 ; A61K31/4192 ; A61K31/42 ; A61K31/421 ; A61K31/422 ; A61K31/423 ; A61K31/427 ; A61K31/4375 ; A61K31/44 ; A61K31/4439 ; A61K31/4709 ; A61K31/4965 ; A61K31/497 ; A61K31/5375 ; A61K31/5377 ; A61P3/04 ; A61P43/00
摘要:
The present invention discloses novel cyclohexane derivatives having NPY Y5 receptor antagonistic activity. Specifically, the present invention discloses a compound represented by the formula (I), or a pharmaceutically acceptable salt or a solvate thereof:
wherein A is substituted or unsubstituted aryl or heterocyclyl; a combination of X and Y is a combination selected from (X, Y)=(C(=O)N(R 1 ), C(=O)N(R 2 )), (C(=O)N(R 1 ), imidazole-1,3-diyl), (N(R 1 ), C(=O)N(R 2 )), (O, C(=O)N(R 2 )), (C(R 3 )(R 4 ), N(R 2 )) or (a single bond, C(=O)N(R 2 )); R 1 , R 2 and R 3 are independently hydrogen or substituted or unsubstituted alkyl; R 5 is substituted or unsubstituted aryl or heterocyclyl; R 6 is halogen, oxo, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy; m is 0 or 1; and n is an integer of 0 to 5; and B is aromatic carbocycle, monocyclic heterocycle or fused bicyclic heterocycle.
wherein A is substituted or unsubstituted aryl or heterocyclyl; a combination of X and Y is a combination selected from (X, Y)=(C(=O)N(R 1 ), C(=O)N(R 2 )), (C(=O)N(R 1 ), imidazole-1,3-diyl), (N(R 1 ), C(=O)N(R 2 )), (O, C(=O)N(R 2 )), (C(R 3 )(R 4 ), N(R 2 )) or (a single bond, C(=O)N(R 2 )); R 1 , R 2 and R 3 are independently hydrogen or substituted or unsubstituted alkyl; R 5 is substituted or unsubstituted aryl or heterocyclyl; R 6 is halogen, oxo, substituted or unsubstituted alkyl, substituted or unsubstituted alkoxy, substituted or unsubstituted aryloxy; m is 0 or 1; and n is an integer of 0 to 5; and B is aromatic carbocycle, monocyclic heterocycle or fused bicyclic heterocycle.
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