发明公开
EP2520281A2 TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF
有权
目标靶向释放系统与PEPTIDMARKIERTEM脂质体特别在拟过程白细胞介素-4受体及其生产诊断和治疗癌症的
- 专利标题： TARGET-AIMING DRUG DELIVERY SYSTEM FOR DIAGNOSIS AND TREATMENT OF CANCER CONTAINING LIPOSOME LABELED WITH PEPTIDES WHICH SPECIFICALLY TARGETS INTERLEUKIN-4 RECEPTORS, AND MANUFACTURING METHOD THEREOF
- 专利标题（中）： 目标靶向释放系统与PEPTIDMARKIERTEM脂质体特别在拟过程白细胞介素-4受体及其生产诊断和治疗癌症的
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申请号： EP10841275.0申请日： 2010-12-29
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公开(公告)号： EP2520281A2公开(公告)日： 2012-11-07
- 发明人: KIM, In San , LEE, Byung Heon , LU, Maggie JM , LIANG, Hsiang-Fa , KO, Yi-Ju , LO, Ya-Chin , CHANG, Li-Wen , WEI, Ming-Cheng
- 申请人： Kyungpook National University Industry- Academic Cooperation Foundation , Industrial Technology Research Institute
- 申请人地址： Kyungpook National University 1370 Sangyeok-dong Buk-gu Daegu 702-701 KR
- 专利权人： Kyungpook National University Industry- Academic Cooperation Foundation,Industrial Technology Research Institute
- 当前专利权人： Kyungpook National University Industry- Academic Cooperation Foundation,Industrial Technology Research Institute
- 当前专利权人地址： Kyungpook National University 1370 Sangyeok-dong Buk-gu Daegu 702-701 KR
- 代理机构： Schwabe - Sandmair - Marx
- 优先权： TW098145476 20091229
- 国际公布： WO2011081443 20110707
- 主分类号： A61K9/127
- IPC分类号： A61K9/127 ; A61K47/30 ; A61K47/18 ; A61K38/20 ; A61P35/00
摘要：
The present invention relates to a target-aiming drug delivery system for diagnosis and treatment of cancer containing liposome labeled with peptides which specifically targets interleukin-4 receptors, and a manufacturing method thereof. The liposome which contains anticancer drugs labeled with IL4RPep peptides prepared in accordance with the present invention can deliver drugs to cancer cells in which IL-4 receptors are overexpressed by IL4RPep peptides which specifically bind to IL-4 receptors, and the drug delivery can recognize cancer cells specifically by a label. Thus, IL4RPep peptides can increase the effect of drugs only on cancer tissues and at the same time significantly reduce the side effects on normal tissues, which makes possible in vivo(molecular) imaging and early diagnosis of tumors. Therefore, the liposome which contains anticancer drugs labeled with IL4Pep peptides of the present invention can be applied, as the target-aiming drug delivery system, effectively to the diagnosis and treatment of cancers.
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