发明授权
EP2657251B1 Live, oral vaccine for protection against Shigella dysenteriae serotype 1
有权
活的口服疫苗，用于预防痢疾志贺菌痢疾血清型1
- 专利标题： Live, oral vaccine for protection against Shigella dysenteriae serotype 1
- 专利标题（中）： 活的口服疫苗，用于预防痢疾志贺菌痢疾血清型1
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申请号： EP13176694.1申请日： 2005-05-24
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公开(公告)号： EP2657251B1公开(公告)日： 2018-03-21
- 发明人: Xu, DeQi , Kopecko, Dennis, J.
- 申请人： The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services
- 申请人地址： National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325 Rockville, MD 20852-3804 US
- 专利权人： The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services
- 当前专利权人： The Government of The United States of America, as represented by The Secretary, Department of Health and Human Services
- 当前专利权人地址： National Institutes of Health Office of Technology Transfer 6011 Executive Boulevard, Suite 325 Rockville, MD 20852-3804 US
- 代理机构： Vossius & Partner Patentanwälte Rechtsanwälte mbB
- 优先权： US574279P 20040524; US609494P 20040913
- 主分类号： C07K14/25
- IPC分类号： C07K14/25 ; A61K39/112 ; C12N15/52
摘要：
The present invention relates to Salmonella typhi Ty21a a comprising core-linked Shigella dysenteriae type 1 O-specific polysaccharide (O-Ps) and DNA encoding O antigen biosynthesis, said DNA selected from the group consisting of: a) the DNA sequence set out in any one of SEQ ID NOs: 1 and 2; b) DNA encoding S. dysenteriae serotype 1 biosynthesis polypeptides encoded by any one of SEQ ID NOs: 1 and 2; c) DNA encoding variants of the polypeptide encoded by the DNA of (a) or (b), wherein the variants comprise O antigen biosynthesis polypeptide analogs, wherein one or more of the specified amino acids is deleted or replaced, or wherein one or more non-specified amino acids are added without loss of biosynthesis of Shigella dysenteriae serotype 1 O antigen or protective immunological activity of the O antigen biosynthesis gene product; and d) nucleic acid molecules encoding gene products that share at least about 90% sequence identity with the polypeptide encoded by the nucleic acid molecule of SEQ ID NO: 1 or 2.
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