发明公开
EP2711368A1 Benzoxazepin PI3K inhibitor compounds and methods of use
有权
苯并西泮-PI3K-Hemmerverbindungen和Anwendungsverfahren
- 专利标题： Benzoxazepin PI3K inhibitor compounds and methods of use
- 专利标题（中）： 苯并西泮-PI3K-Hemmerverbindungen和Anwendungsverfahren
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申请号： EP13193562.9申请日： 2010-09-27
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公开(公告)号： EP2711368A1公开(公告)日： 2014-03-26
- 发明人: Blaquiere, Nicole , Do, Steven , Dudley, Danette , Folkes, Adrian J. , Heald, Robert , Heffron, Timothy , Jones, Mark , Kolesnikov, Aleksandr , Ndubaku, Chudi , Olivero, Alan G. , Price, Stephen , Staben, Steven , Wang, Lan
- 申请人： F. Hoffmann-La Roche AG
- 申请人地址： Grenzacherstrasse 124 4070 Basel CH
- 专利权人： F. Hoffmann-La Roche AG
- 当前专利权人： F. Hoffmann-La Roche AG
- 当前专利权人地址： Grenzacherstrasse 124 4070 Basel CH
- 代理机构： Sauer, Frank
- 优先权： US246381P 20090928; US330685P 20100503
- 主分类号： C07D498/04
- IPC分类号： C07D498/04 ; C07D498/14 ; C07D519/00 ; A61K31/4162 ; A61K31/4188 ; A61K31/4196 ; A61P35/00
摘要：
The invention relates to benzoxazepin compounds of Formula I
including stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: Z 1 is CR 1 or N; Z 2 is CR 2 or N; Z 3 is CR 3 or N; Z 4 is CR 4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring which compounds have anti-cancer activity, and more specifically, inhibit PI3 kinase activity.
including stereoisomers, geometric isomers, tautomers, or pharmaceutically acceptable salts thereof, wherein: Z 1 is CR 1 or N; Z 2 is CR 2 or N; Z 3 is CR 3 or N; Z 4 is CR 4 or N; and B is a pyrazolyl, imidazolyl, or triazolyl ring which compounds have anti-cancer activity, and more specifically, inhibit PI3 kinase activity.
公开/授权文献
- EP2711368B1 Benzoxazepin PI3K inhibitor compounds and methods of use 公开/授权日：2016-03-23
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