- 专利标题: CYCLOPROPANEAMINE COMPOUND
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申请号: EP12821416申请日: 2012-08-08
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公开(公告)号: EP2743256B1公开(公告)日: 2018-06-27
- 发明人: TOMITA NAOKI , KAJII SHIGEO , CARY DOUGLAS ROBERT , TOMITA DAISUKE , IMAMURA SHINICHI , TSUCHIDA KEN , MATSUDA SATORU , HARA RYUJIRO
- 申请人: TAKEDA PHARMACEUTICALS CO
- 专利权人: TAKEDA PHARMACEUTICALS CO
- 当前专利权人: TAKEDA PHARMACEUTICALS CO
- 优先权: JP2011174305 2011-08-09
- 主分类号: C07C233/80
- IPC分类号: C07C233/80 ; A61K31/167 ; A61K31/36 ; A61K31/366 ; A61K31/381 ; A61K31/40 ; A61K31/402 ; A61K31/4035 ; A61K31/404 ; A61K31/4184 ; A61K31/42 ; A61K31/421 ; A61K31/426 ; A61K31/428 ; A61K31/429 ; A61K31/433 ; A61K31/4406 ; A61K31/4409 ; A61K31/4453 ; A61K31/4468 ; A61K31/451
摘要:
The present invention provides a compound having a lysine-specific demethylase 1 inhibitory action, and useful as a medicament such as a prophylactic or therapeutic agent for cancer, and central nervous system diseases, and the like. The present invention relates to a compound represented by the formula wherein A is a hydrocarbon group or heterocyclic group optionally having substituent(s); R is H, a hydrocarbon group or heterocyclic group optionally having substituent(s); A and R are optionally bonded to each other to form a ring optionally having substituent(s); Q 1 , Q 2 , Q 3 and Q 4 are each a hydrogen atom or a substituent; Q 1 and Q 2 , and Q 3 and Q 4 , are each optionally bonded to each other to form a ring optionally having substituent(s); X is H, an acyclic hydrocarbon group or saturated cyclic group optionally having substituent(s); Y 1 , Y 2 and Y 3 are each H, a hydrocarbon group or heterocyclic group optionally having substituent(s); X and Y 1 , and Y 1 and Y 2 , are each optionally bonded to each other to form a ring optionally having substituent(s); and Z 1 , Z 2 and Z 3 are each H or a substituent, or a salt thereof.
公开/授权文献
- EP2743256A4 CYCLOPROPANEAMINE COMPOUND 公开/授权日:2015-05-13
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