发明授权
EP2804872B1 NORBORNENE MODIFIED PEPTIDES AND THEIR LABELLING WITH TETRAZINE COMPOUNDS
有权
诺丁宁修饰肽及其与四嗪类化合物的标记
- 专利标题： NORBORNENE MODIFIED PEPTIDES AND THEIR LABELLING WITH TETRAZINE COMPOUNDS
- 专利标题（中）： 诺丁宁修饰肽及其与四嗪类化合物的标记
-
申请号： EP13711926.9申请日： 2013-01-21
-
公开(公告)号： EP2804872B1公开(公告)日： 2018-03-21
- 发明人: CHIN, Jason , DEITERS, Alexander , LANG, Kathrin
- 申请人： Medical Research Council , North Carolina State University
- 申请人地址： 2nd Floor David Phillips Building Polaris House North Star Avenue Swindon SN2 1FL GB
- 专利权人： Medical Research Council,North Carolina State University
- 当前专利权人： Medical Research Council,North Carolina State University
- 当前专利权人地址： 2nd Floor David Phillips Building Polaris House North Star Avenue Swindon SN2 1FL GB
- 代理机构： Script IP Limited
- 优先权： US201261588948P 20120120; GB201201100 20120120
- 国际公布： WO2013108044 20130725
- 主分类号： C07K1/13
- IPC分类号： C07K1/13 ; A61K49/00 ; C12P21/02 ; C07C271/34 ; C12N9/00 ; G01N33/58
摘要：
The invention relates to a polypeptide comprising an amino acid having a norbornene group. Suitably said norbornene group is present as an amino acid residue of a norbornene lysine. The invention also relates to a method of producing a polypeptide comprising a norbornene group, said method comprising genetically incorporating an amino acid comprising a norbornene group into a polypeptide. The polypeptide comprising the norbornene group can be specifically labelled by inverse electron demand Diels-Alder reaction with a tetrazine compound.
公开/授权文献
信息查询
