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    NORBORNENE MODIFIED PEPTIDES AND THEIR LABELLING WITH TETRAZINE COMPOUNDS
    5.
    发明公开
    NORBORNENE MODIFIED PEPTIDES AND THEIR LABELLING WITH TETRAZINE COMPOUNDS 有权
    万古霉素治疗恶性肿瘤细胞毒素TETRAZINVERBINDUNGEN

    公开(公告)号：EP2804872A2

    公开(公告)日：2014-11-26

    申请号：EP13711926.9

    申请日：2013-01-21

    申请人： Medical Research Council ,  North Carolina State University

    发明人： CHIN, Jason ,  DEITERS, Alexander

    IPC分类号： C07K1/13 ,  A61K49/00 ,  C12P21/02

    CPC分类号： A61K49/0017 ,  C07C271/34 ,  C07C2601/16 ,  C07C2602/42 ,  C07K1/13 ,  C12N9/93 ,  C12P21/02 ,  C12Y601/01026 ,  G01N33/582

    摘要： The invention relates to a polypeptide comprising an amino acid having a norbornene group. Suitably said norbornene group is present as an amino acid residue of a norbornene lysine. The invention also relates to a method of producing a polypeptide comprising a norbornene group, said method comprising genetically incorporating an amino acid comprising a norbornene group into a polypeptide. The polypeptide comprising the norbornene group can be specifically labelled by inverse electron demand Diels-Alder reaction with a tetrazine compound.

    摘要翻译： 本发明涉及包含具有降冰片烯基团的氨基酸的多肽。 适当地说，降冰片烯基团作为降冰片烯赖氨酸的氨基酸残基存在。 本发明还涉及生产包含降冰片烯基团的多肽的方法，所述方法包括将包含降冰片烯基团的氨基酸遗传并入多肽中。 包含降冰片烯基团的多肽可以通过与四嗪化合物的反电子需求狄尔斯 - 阿尔德反应来具体标记。

    METHOD FOR INCORPORATING ALIPHATIC AMINO ACIDS COMPRISING ALKYNE, AZIDE OR ALIPHATIC KETONE FUNCTIONAL GROUPS USING APPROPRIATE TRNA/TRNA SYNTHASE PAIRS
    6.
    发明公开
    METHOD FOR INCORPORATING ALIPHATIC AMINO ACIDS COMPRISING ALKYNE, AZIDE OR ALIPHATIC KETONE FUNCTIONAL GROUPS USING APPROPRIATE TRNA/TRNA SYNTHASE PAIRS 有权
    METHOD FOR与具有相关的tRNA酶/ tRNA-SYNTHASEPAAREN脂族氨基炔叠氮化或脂族酮FUNCTIONAL RECORDING

    公开(公告)号：EP2438174A2

    公开(公告)日：2012-04-11

    申请号：EP10727116.5

    申请日：2010-06-02

    申请人： Medical Research Council Technology ,  North Carolina State University

    发明人： NGUYEN, Duy, P. ,  NEUMANN, Heinz ,  DEITERS, Alexander ,  CHIN, Jason ,  LUSIC, Hrvoje

    IPC分类号： C12N15/67

    CPC分类号： C12N15/67 ,  C07C233/49 ,  C07C271/22 ,  C12N9/93 ,  C12P21/02

    摘要： The invention relates to a method of making a polypeptide comprising an orthogonal functional group, said orthogonal functional group being comprised by an aliphatic amino acid or amino acid derivative, said method comprising providing a host cell; providing a nucleic acid encoding the polypeptide of interest; providing a tRNA-tRNA synthetase pair orthogonal to said host cell; adding an amino acid or amino acid derivative comprising the orthogonal functional group of interest, wherein said amino acid or amino acid derivative is a substrate for said orthogonal tRNA synthetase, wherein said amino acid or amino acid derivative has an aliphatic carbon backbone; and incubating to allow incorporation of said amino acid or amino acid derivative into the polypeptide of interest via the orthogonal tRNA-tRNA synthetase pair. The invention also relates to certain amino acids, and to polypeptides comprising same.

    摘要翻译： 本发明涉及一种制造多肽，其包含正交官能团的方法，所述正交官能团被在脂肪族氨基酸或氨基酸衍生物组成，所述方法包括提供宿主细胞; 提供核酸编码感兴趣的多肽; 提供的tRNA-tRNA合成酶对正交于所述宿主细胞; 添加于氨基酸或氨基酸衍生物包含所关注的正交官能团，worin所述氨基酸或氨基酸衍生物为所述正交tRNA合成酶底物一，worin所述氨基酸或氨基酸衍生物具有脂族碳主链; 孵育，并允许所说的氨基酸或氨基酸衍生物的掺入的经由正交tRNA合成酶-tRNA对感兴趣的多肽。 因此，本发明涉及某些氨基酸，以及多肽，其包含相同。