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1.发明授权
公开(公告)号：EP2804872B1
公开(公告)日：2018-03-21
申请号：EP13711926.9
申请日：2013-01-21
发明人： CHIN, Jason , DEITERS, Alexander , LANG, Kathrin
CPC分类号： A61K49/0017 , C07C271/34 , C07C2601/16 , C07C2602/42 , C07K1/13 , C12N9/93 , C12P21/02 , C12Y601/01026 , G01N33/582
摘要： The invention relates to a polypeptide comprising an amino acid having a norbornene group. Suitably said norbornene group is present as an amino acid residue of a norbornene lysine. The invention also relates to a method of producing a polypeptide comprising a norbornene group, said method comprising genetically incorporating an amino acid comprising a norbornene group into a polypeptide. The polypeptide comprising the norbornene group can be specifically labelled by inverse electron demand Diels-Alder reaction with a tetrazine compound.
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2.发明授权METHODS OF INCORPORATING AN AMINO ACID COMPRISING A BCN GROUP INTO A POLYPEPTIDE USING AN ORTHOGONAL CODON ENCODING IT AND AN ORTHORGONAL PYLRS SYNTHASE. 有权将包含BCN基团的氨基酸并入多肽中的方法，其中使用编码它的正交密码子和ORGORALPYLRS合成酶。
公开(公告)号：EP2852664B1
公开(公告)日：2017-09-06
申请号：EP13734818.1
申请日：2013-05-15
发明人： CHIN, Jason , LANG, Kathrin
CPC分类号： G01N33/582 , C07C271/22 , C07C2602/24 , C07K1/006 , C07K1/13 , C07K2/00 , C12N9/93 , C12Y601/01026
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3.发明公开METHODS OF INCORPORATING AN AMINO ACID COMPRISING A BCN GROUP INTO A POLYPEPTIDE USING AN ORTHOGONAL CODON ENCODING IT AND AN ORTHORGONAL PYLRS SYNTHASE. 有权引入氨基乙酸，BCN组中的多肽使用一个正交编码密码子方法以及一个ORTHORGONALEN发展的PylRS合酶
公开(公告)号：EP2852664A1
公开(公告)日：2015-04-01
申请号：EP13734818.1
申请日：2013-05-15
发明人： CHIN, Jason , LANG, Kathrin
CPC分类号： G01N33/582 , C07C271/22 , C07C2602/24 , C07K1/006 , C07K1/13 , C07K2/00 , C12N9/93 , C12Y601/01026
摘要： The invention relates to a polypeptide comprising an amino acid having a bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) group, particularly when said BCN group is present as: a residue of a lysine amino acid. The invention also relates to a method of producing a polypeptide comprising a BCN group, said method comprising genetically incorporating an amino acid comprising a BCN group into a polypeptide. The invention also relates to an amino acid comprising bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN), particularly and amino acid which is bicyclo[6.1.0]non-4-yn-9-ylmethanol (BCN) lysine. In addition the invention relates to a PylRS tRNA synthetase comprising the mutations Y271M, L274G and C313A.
摘要翻译： 本发明涉及包含具有双环[6.1.0]壬-4-炔-9-基甲醇（BCN）基团，尤其是当所述BCN基团存在的氨基酸的多肽：赖氨酸氨基酸的残基。 因此，本发明涉及产生多肽，包括一组BCN，所述方法包括在转基因氨基酸掺入包含BCN组成多肽的方法。 因此，本发明涉及在氨基酸包括二环[6.1.0]壬-4-炔-9-基甲醇（BCN），特别是氨基酸和所有其是双环[6.1.0]壬-4-炔-9-基甲醇（ BCN）赖氨酸。 此外，本发明涉及一个tRNA合成酶进化的PylRS包含突变Y271M，L274G和C313A。
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