发明公开
EP2816035A3 Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction
审中-公开
作为突变CFTR蛋白调节剂的化合物及其用于治疗与CFTR蛋白功能失调相关的疾病的用途
- 专利标题： Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction
- 专利标题（中）： 作为突变CFTR蛋白调节剂的化合物及其用于治疗与CFTR蛋白功能失调相关的疾病的用途
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申请号： EP14185333.3申请日： 2011-06-20
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公开(公告)号： EP2816035A3公开(公告)日： 2015-02-25
- 发明人: Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
- 申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk
- 申请人地址： Adolfa Pawinskiego 5A 02-106 Warszawa PL
- 专利权人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk
- 当前专利权人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk
- 当前专利权人地址： Adolfa Pawinskiego 5A 02-106 Warszawa PL
- 代理机构： Twardowska, Aleksandra
- 优先权： PL39239610P 20100914; PL39239710P 20100914
- 主分类号： C07D219/10
- IPC分类号： C07D219/10 ; C07D473/30 ; C07F9/30 ; C07C233/65 ; A61K31/663 ; A61K31/435 ; A61K31/522 ; A61K31/194 ; A61P11/00 ; C07D401/12 ; C07C235/84 ; C07D473/22
摘要：
The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
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