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1.发明公开
公开(公告)号：EP2826771A2
公开(公告)日：2015-01-21
申请号：EP14185330.9
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
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公开(公告)号：EP2826771B1
公开(公告)日：2018-12-12
申请号：EP14185330.9
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D401/12 , C07C235/84 , C07D473/22 , A61K31/496 , A61K31/52
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ”F508-CFTR, or another mutation of class II.
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3.发明公开Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction 审中-公开化合物作为突变CFTR蛋白的调节剂和其用于治疗疾病与CFTR蛋白故障相关联的治疗用途
公开(公告)号：EP2816034A2
公开(公告)日：2014-12-24
申请号：EP14185332.5
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D473/22 , C07D401/12 , C07C235/84
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
摘要翻译： 本发明涉及一种能够改变突变体CFTR蛋白的功能和它们用于治疗与CFTR蛋白故障有关的疾病的使用新颖蛋白调节剂。 本发明提供了组合物，药物制剂和校正的突变CFTR蛋白worin的CFTR突变的细胞改变是突变“F508-CFTR，或II类的另一突变的方法。
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4.发明公开Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction 审中-公开作为突变CFTR蛋白调节剂的化合物及其用于治疗与CFTR蛋白功能失调相关的疾病的用途
公开(公告)号：EP2816035A3
公开(公告)日：2015-02-25
申请号：EP14185333.3
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D401/12 , C07C235/84 , C07D473/22
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
摘要翻译： 本发明涉及能够改变突变CFTR蛋白功能的新颖蛋白调节剂及其用于治疗与CFTR蛋白功能失调有关的疾病的用途。 本发明提供了校正突变CFTR蛋白的细胞改变的组合物，药物制剂和方法，其中CFTR突变是ΔF508-CFTR突变或II类另一突变。
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公开(公告)号：EP2816034B1
公开(公告)日：2018-12-12
申请号：EP14185332.5
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D473/22 , C07D401/12 , C07C235/84 , A61K31/496 , A61K31/52
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ”F508-CFTR, or another mutation of class II.
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6.发明公开Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction 审中-公开化合物作为突变CFTR蛋白的调节剂和其用于治疗疾病与CFTR蛋白故障相关联的治疗用途
公开(公告)号：EP2816034A3
公开(公告)日：2015-03-04
申请号：EP14185332.5
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D473/22 , C07D401/12 , C07C235/84
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
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7.发明公开Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction 审中-公开化合物作为突变CFTR蛋白的调节剂及其对疾病与CFTR蛋白功能障碍相关的治疗用途
公开(公告)号：EP2826771A3
公开(公告)日：2015-02-18
申请号：EP14185330.9
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D401/12 , C07C235/84 , C07D473/22
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
摘要翻译： 本发明涉及一种能够改变突变体CFTR蛋白的功能和它们用于治疗与CFTR蛋白故障有关的疾病的使用新颖蛋白调节剂。 本发明提供了组合物，药物制剂和校正的突变CFTR蛋白worin的CFTR突变的细胞改变是突变“F508-CFTR，或II类的另一突变的方法。
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8.发明公开Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction 审中-公开化合物作为突变CFTR蛋白调制器和它们用于疾病治疗的蛋白质CFTR障碍有关
公开(公告)号：EP2816035A2
公开(公告)日：2014-12-24
申请号：EP14185333.3
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D401/12 , C07C235/84 , C07D473/22
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
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