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公开(公告)号：EP3456813B1
公开(公告)日：2021-04-28
申请号：EP18195200.3
申请日：2015-08-31
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2.发明公开ENTEROCOCCUS FAECALIS STRAINS FOR THE PRODUCTION OF BACTERIOPHAGE PREPARATIONS 审中-公开Enterococcus FAECALIS菌株用于生产噬菌体制剂
公开(公告)号：EP3186361A1
公开(公告)日：2017-07-05
申请号：EP15778720.1
申请日：2015-08-31
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii i Terapii Doswiadczalnej Polskiej Akademii Nauk
发明人： LOBOCKA, Malgorzata , GOZDEK, Agnieszka , IZAK, Dariusz , ZALEWSKA, Agnieszka , GAWOR, Jan , DABROWSKI, Kamil , GROMADKA, Robert , WEBER-DABROWSKA, Beata , GÓRSKI, Andrzej
CPC分类号： C12R1/46 , C12N7/00 , C12N2795/00051
摘要： Disclosed are Enterococcus faecalis strains for obtaining monoclonal preparations of lytic bacteriophages with high titer, particularly devoid of contamination with undesired bacteriophages, the strains guaranteeing the production of safe to use bacteriophage preparations, not being a source of dissemination of genes associated with bacterial virulence.
摘要翻译： 公开了粪肠球菌菌株用于获得具有高效价的溶解性噬菌体的单克隆制备物，特别是没有不希望的噬菌体污染，所述菌株保证产生安全使用的噬菌体制剂，而不是与细菌毒力相关的基因传播的来源。
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3.发明公开TRANSCRIPTOMIC BIOMARKERS, METHOD FOR DETERMINATION THEREOF AND USE OF TRNASCRIPTOMIC BIOMARKERS FOR INDIVIDUAL RISK ASSESSMENT OF DEVELOPING POST-INFRACTION HEART FAILURE 审中-公开转录生物标记物的方法来确定哪些和心衰的发展评估个体风险转录组生物标记物的使用后梗死
公开(公告)号：EP3105350A2
公开(公告)日：2016-12-21
申请号：EP15712187.2
申请日：2015-02-12
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Warszawski Uniwersytet Medyczny , Uniwersytet Medyczny W Bia Ymstoku
发明人： BURZYNSKA, Beata , GÓRA, Monika , MACIEJAK, Agata , TULACZ, Dorota , KILISZEK, Marek , MICHALAK, Marcin , OPOLSKI, Grzegorz , MATLAK, Krzysztof , DOBRZYCKI, Slawomir
IPC分类号： C12Q1/68
CPC分类号： C12Q1/6883 , C12Q2600/106 , C12Q2600/158
摘要： The invention relates to biomarkers for individual risk assessment of the development of post-infarction heart failure, the method of determining the markers in samples of biological material collected from a patient. Further, the invention relates to a use of the biomarkers in the diagnosis (expression level of the gene) that correlate with the developing post-infarction heart failure, and enable prevention of heart disease based on a genetic marker and a method for predicting the risk of developing a heart failure for post-infarction patients. Also a method for optimizing the treatment of cardiac patients with the use of the means of the invention is disclosed.
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4.发明公开HORSE CHESTNUT EXTRACT OR ESCINS FOR THE TREATMENT OF ALZHEIMER'S DISEASE 审中-公开EXTRAKT VONGEWÖHNLICHERROSSKASTANIE ODER AESCINS ZUR BEHANDLUNG冯ALZHEIMER-KRANKHEIT
公开(公告)号：EP3078381A1
公开(公告)日：2016-10-12
申请号：EP15001035.3
申请日：2015-04-10
申请人： Warszawski Uniwersytet Medyczny , INSTYTUT FARMACEUTYCZNY , Instytut Biochemii I Biofizyki Polskiej Akademii Nauk
发明人： Koziak, Katarzyna , Kowalewska, Magdalena , Maciejko, Dorota , Zegrocka-Stendel, Oliwia , Domanski, Dominik , Perzanowska, Anna
CPC分类号： A61K36/77
摘要： The subject invention relates to agents for use in treatment and/or prevention of Alzheimer's disease. The group of agents include horse chestnut extract, escins, their salts and derivatives.
摘要翻译： 本发明涉及用于治疗和/或预防阿尔茨海默病的药剂。 该组代理包括马蹄提取物，海鞘，其盐和衍生物。
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5.发明公开
公开(公告)号：EP2826771A2
公开(公告)日：2015-01-21
申请号：EP14185330.9
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
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6.发明公开
公开(公告)号：EP3469372A1
公开(公告)日：2019-04-17
申请号：EP17736762.0
申请日：2017-06-12
发明人： MUCHA, Krzysztof , PACZEK, Leszek , ZAGOZDZON, Radoslaw , FORONCEWICZ, Bartosz , DADLEZ, Michal , BAKUN, Magdalena , PIWOWARSKI, Jan , PILZYS, Tomas , MARCINKOWSKI, Michal , GARBICZ, Damian , GRZESIUK, Elzbieta , FLORCZAK, Michal
IPC分类号： G01N33/68
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公开(公告)号：EP2826771B1
公开(公告)日：2018-12-12
申请号：EP14185330.9
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D401/12 , C07C235/84 , C07D473/22 , A61K31/496 , A61K31/52
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ”F508-CFTR, or another mutation of class II.
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8.发明公开METHOD FOR SELECTION OF HDIS3 PIN DOMAIN INHIBITORS AND USE OF HDIS3 PIN DOMAIN INHIBITORS FOR CANCER TREATMENT 有权HDIS3 PIN结构域抑制剂的选择及HDIS3 PIN域抑制剂为癌症治疗
公开(公告)号：EP2999789A1
公开(公告)日：2016-03-30
申请号：EP14733705.9
申请日：2014-05-20
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , ONCOARENDI THERAPEUTICS SP. Z.O.O. , Miedzynarodowy Instytut Biologii Molekularnej I Komorkowej
发明人： DZIEMBOWSKI, Andrzej , TOMECKI, Rafal , DRAZKOWSKA, Karolina , SZCZESNY, Roman , STODUS, Krystian , JONKO, Weronika , NOWOTNY, Marcin , GOLEBIOWSKI, Adam , OLCZAK, Jacek
IPC分类号： C12N15/81
CPC分类号： C12Q1/6897 , A61K31/472 , C12N15/81 , C12Q1/18 , G01N33/5008 , G01N33/5011 , G01N33/5038 , G01N33/573 , G01N2333/916 , G01N2333/922 , G01N2500/04 , G01N2500/10
摘要： The present invention relates to a method for selection or screening of hDIS3 PIN domain inhibitors, yeast strain and cell line used in such methods It also relates to new therapeutic agents selected hDIS3 PIN domain inhibitors and uses thereof in the treatment of cancers having mutations inhDIS3 RNB domain, especially multiple myeloma. The invention also relates to composition comprising new therapeutic agent hDIS3 PIN domain inhibitor and method for inducing synthetic lethality in a cancer cell.
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9.发明公开A METHOD OF EVALUATING THE THERAPEUTIC EFFICACY OF BACTERIOPHAGES 有权VERFAHREN ZUR BEWERTUNG DER THERAPEUTISCHEN WIRKSAMKEIT VON BAKTERIOPHAGEN
公开(公告)号：EP2872156A1
公开(公告)日：2015-05-20
申请号：EP13741984.2
申请日：2013-07-13
申请人： Instytut Biochemii I Biofizyki Polskiej Akademii Nauk , Instytut Immunologii I Terapii Doswiadczalnej Polskiej Akademii Nauk , Narodowy Instytut Leków , Szkola Glówna Gospodarstwa Wiejskiego W Warszawie , Wojskowy Instytut Higieny I Epidemiologii
发明人： LOBOCKA, Malgorzata , GLOWACKA, Aleksandra , DABROWSKI, Kamil , HEJNOWICZ, Monika S. , GOZDEK, Agnieszka , WEBER-DABROWSKA, Beata , GÓRSKI, Andrzej , EMPEL, Joanna , HRYNIEWICZ, Waleria , KWIATEK, Magdalena , PARASION, Sylwia , GRYKO, Romuald
IPC分类号： A61K35/76
CPC分类号： G01N33/5085 , A61K35/76 , G01N2333/4353 , Y02A50/475 , Y02A50/481
摘要： The subject of the present invention is a novel use of a nematode in the evaluation of the therapeutic efficacy of bacteriophage preparations used in, or capable of being used in the treatment of infections caused by pathogenic bacteria in humans or animals.
摘要翻译： 本发明的主题是线虫评估用于或能够用于治疗由人或动物中的病原菌引起的感染的噬菌体制剂的治疗功效的新用途。
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10.发明公开Compounds as modulators of a mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction 审中-公开化合物作为突变CFTR蛋白的调节剂和其用于治疗疾病与CFTR蛋白故障相关联的治疗用途
公开(公告)号：EP2816034A2
公开(公告)日：2014-12-24
申请号：EP14185332.5
申请日：2011-06-20
发明人： Odolczyk, Norbert , Zielenkiewicz, Piotr , Wieczorek, Grzegorz , Edelman, Aleksander , Tondelier, Danielle , Fritsch, Janine
IPC分类号： C07D219/10 , C07D473/30 , C07F9/30 , C07C233/65 , A61K31/663 , A61K31/435 , A61K31/522 , A61K31/194 , A61P11/00 , C07D473/22 , C07D401/12 , C07C235/84
CPC分类号： A61K31/194 , A61K31/496 , A61K31/52 , A61K31/663 , C07C233/65 , C07C235/84 , C07C2603/18 , C07D219/10 , C07D401/12 , C07D473/22 , C07D473/30 , C07F9/304 , C07F9/305
摘要： The present invention relates to novel protein modulators capable of altering function of the mutant CFTR protein and their use for treating diseases associated with CFTR protein malfunction. The invention provides compositions, pharmaceutical preparations and methods of correcting the cellular alteration of a mutant CFTR protein wherein the CFTR mutation is a mutation ΔF508-CFTR, or another mutation of class II.
摘要翻译： 本发明涉及一种能够改变突变体CFTR蛋白的功能和它们用于治疗与CFTR蛋白故障有关的疾病的使用新颖蛋白调节剂。 本发明提供了组合物，药物制剂和校正的突变CFTR蛋白worin的CFTR突变的细胞改变是突变“F508-CFTR，或II类的另一突变的方法。
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