发明公开
EP2847214A1 ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
有权
MANIPULIERTE IMINREDUKTASEN UND VERFAHREN ZUR REDUKTIVEN AMINIERUNG VON KETON- UND AMINVERBINDUNGEN
- 专利标题： ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS
- 专利标题（中）： MANIPULIERTE IMINREDUKTASEN UND VERFAHREN ZUR REDUKTIVEN AMINIERUNG VON KETON- UND AMINVERBINDUNGEN
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申请号： EP13724127.9申请日： 2013-05-09
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公开(公告)号： EP2847214A1公开(公告)日： 2015-03-18
- 发明人: CHEN, Haibin , MOORE, Jeffrey , COLLIER, Steven J. , SMITH, Derek , NAZOR, Jovana , HUGHES, Gregory , JANEY, Jacob , HUISMAN, Gjalt , NOVICK, Scott , AGARD, Nicholas , ALVIZO, Oscar , COPE, Gregory , YEO, Wan Lin , SUKUMARAN, Joly , MINOR, Stefanie, Ng
- 申请人： Codexis, Inc.
- 申请人地址： 200 Penobscot Drive Redwood City, CA 94063 US
- 专利权人： Codexis, Inc.
- 当前专利权人： Codexis, Inc.
- 当前专利权人地址： 200 Penobscot Drive Redwood City, CA 94063 US
- 代理机构： Chapman, Desmond Mark
- 优先权： US201261646100P 20120511
- 国际公布： WO2013170050 20131114
- 主分类号： C07K14/435
- IPC分类号： C07K14/435
摘要：
The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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