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1.发明公开ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS 有权MANIPULIERTE IMINREDUKTASEN UND VERFAHREN ZUR REDUKTIVEN AMINIERUNG VON KETON- UND AMINVERBINDUNGEN
公开(公告)号：EP2847214A1
公开(公告)日：2015-03-18
申请号：EP13724127.9
申请日：2013-05-09
申请人： Codexis, Inc.
发明人： CHEN, Haibin , MOORE, Jeffrey , COLLIER, Steven J. , SMITH, Derek , NAZOR, Jovana , HUGHES, Gregory , JANEY, Jacob , HUISMAN, Gjalt , NOVICK, Scott , AGARD, Nicholas , ALVIZO, Oscar , COPE, Gregory , YEO, Wan Lin , SUKUMARAN, Joly , MINOR, Stefanie, Ng
IPC分类号： C07K14/435
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译： 本公开提供了具有亚胺还原酶活性的工程化多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。
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公开(公告)号：EP2697662B1
公开(公告)日：2018-06-06
申请号：EP12771861.7
申请日：2012-04-12
申请人： Codexis, Inc.
发明人： GOHEL, Anupam , SMITH, Derek , WONG, Brian , SUKUMARAN, Joly , YEO, Wan Lin , COLLIER, Steven, J. , NOVICK, Scott
CPC分类号： C12P17/10 , C07D223/22 , C07D223/28 , C07D453/02 , C12N9/0006 , C12N9/004 , C12N11/00 , C12P41/002 , C12Y101/00 , Y02P20/52
摘要： The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
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3.发明授权ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS 有权用于酮和胺化合物的还原胺化的工程化亚胺减少物和方法
公开(公告)号：EP2847214B1
公开(公告)日：2017-12-27
申请号：EP13724127.9
申请日：2013-05-09
申请人： Codexis, Inc.
发明人： CHEN, Haibin , MOORE, Jeffrey , COLLIER, Steven J. , SMITH, Derek , NAZOR, Jovana , HUGHES, Gregory , JANEY, Jacob , HUISMAN, Gjalt , NOVICK, Scott , AGARD, Nicholas , ALVIZO, Oscar , COPE, Gregory , YEO, Wan Lin , SUKUMARAN, Joly , MINOR, Stefanie, Ng
IPC分类号： C07K14/435
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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公开(公告)号：EP3190123A1
公开(公告)日：2017-07-12
申请号：EP16201269.4
申请日：2010-09-24
申请人： Codexis, Inc.
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
摘要翻译： 提出了使用LovD酰基转移酶，具有酰基的硫酯和（i）硫醇清除剂和/或（ii）沉淀剂改善化学底物酰化的方法。 还提出了使用（i）活性炭作为硫醇清除剂和/或（ii）氢氧化铵作为沉淀剂生产辛伐他汀的改进方法。
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公开(公告)号：EP2946006A1
公开(公告)日：2015-11-25
申请号：EP14740809.0
申请日：2014-01-16
申请人： Codexis, Inc.
发明人： SUKUMARAN, Joly , SMITH, Derek , YANG, Hong , YEO, Wan Lin , MOORE, Jeffrey, C.
IPC分类号： C12N1/21
CPC分类号： C12N9/18 , C12P11/00 , C12P17/184 , C12Y301/01 , Y02P20/52
摘要： The present disclosure provides engineered pNB esterase polypeptides useful for the synthesis of the carbapenem antibiotic, imipenem. The disclosure also provides polynucleotides encoding the engineered pNB esterases, host cells capable of expressing the engineered pNB esterases, and methods of using the engineered pNB esterases in the production of imipenem.
摘要翻译： 本公开提供了可用于合成碳青霉烯类抗生素亚胺培南的工程化pNB酯酶多肽。 本公开还提供了编码工程化pNB酯酶的多核苷酸，能够表达工程化pNB酯酶的宿主细胞，以及在亚胺培南生产中使用工程化pNB酯酶的方法。
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公开(公告)号：EP2946006B1
公开(公告)日：2019-04-10
申请号：EP14740809.0
申请日：2014-01-16
申请人： Codexis, Inc.
发明人： SUKUMARAN, Joly , SMITH, Derek , YANG, Hong , YEO, Wan Lin , MOORE, Jeffrey C.
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公开(公告)号：EP2483293B1
公开(公告)日：2016-11-30
申请号：EP10821066.7
申请日：2010-09-24
申请人： Codexis, Inc.
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
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8.发明公开BIOCATALYTIC PROCESS FOR PREPARING ESLICARBAZEPINE AND ANALOGS THEREOF 有权生物技术维多利亚ZUR HERSTELLUNG VON ESLICARBAZEPIN UND ANALOGA DAVON
公开(公告)号：EP2697662A2
公开(公告)日：2014-02-19
申请号：EP12771861.7
申请日：2012-04-12
申请人： Codexis, Inc.
发明人： GOHEL, Anupam , SMITH, Derek , WONG, Brian , SUKUMARAN, Joly , YEO, Wan Lin , COLLIER, Steven, J. , NOVICK, Scott
IPC分类号： G01S1/06
CPC分类号： C12P17/10 , C07D223/22 , C07D223/28 , C07D453/02 , C12N9/0006 , C12N9/004 , C12N11/00 , C12P41/002 , C12Y101/00 , Y02P20/52
摘要： The present disclosure relates to biocatalysts and its uses for the efficient preparation of eslicarbazepine, eslicarbazepine acetate, and analogs thereof.
摘要翻译： 本公开涉及生物催化剂及其用于有效制备西酞西泮，醋酸西拉西平及其类似物的用途。
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10.发明授权
公开(公告)号：EP2483292B1
公开(公告)日：2014-11-12
申请号：EP10821065.9
申请日：2010-09-24
申请人： Codexis, Inc.
发明人： GILSON, Lynne , COLLIER, Steven James , SUKUMARAN, Joly , YEO, Wan Lin , ALVISO, Oscar , TEO, Ee Ling , WILSON, Robert John , XU, Junye
CPC分类号： C12P17/06 , C07K14/00 , C12N9/1025 , C12N9/1029 , C12N15/52 , C12P7/62 , C12Y203/01 , Y02P20/52
摘要： Methods for the improved acylation of chemical substrates using LovD acyltransferases, thioesters having acyl groups, and (i) thiol scavengers and/or (ii) precipitating agents are presented. An improved method for the production of simvastatin using (i) activated charcoal as a thiol scavenger and/or (ii) ammonium hydroxide as a precipitating agent is also presented.
摘要翻译： 本公开提供了可用于合成治疗重要的他汀类化合物的酰基转移酶。
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