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1.发明公开ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS 有权MANIPULIERTE IMINREDUKTASEN UND VERFAHREN ZUR REDUKTIVEN AMINIERUNG VON KETON- UND AMINVERBINDUNGEN
公开(公告)号：EP2847214A1
公开(公告)日：2015-03-18
申请号：EP13724127.9
申请日：2013-05-09
申请人： Codexis, Inc.
发明人： CHEN, Haibin , MOORE, Jeffrey , COLLIER, Steven J. , SMITH, Derek , NAZOR, Jovana , HUGHES, Gregory , JANEY, Jacob , HUISMAN, Gjalt , NOVICK, Scott , AGARD, Nicholas , ALVIZO, Oscar , COPE, Gregory , YEO, Wan Lin , SUKUMARAN, Joly , MINOR, Stefanie, Ng
IPC分类号： C07K14/435
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译： 本公开提供了具有亚胺还原酶活性的工程化多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。
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2.发明授权ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS 有权用于酮和胺化合物的还原胺化的工程化亚胺减少物和方法
公开(公告)号：EP2847214B1
公开(公告)日：2017-12-27
申请号：EP13724127.9
申请日：2013-05-09
申请人： Codexis, Inc.
发明人： CHEN, Haibin , MOORE, Jeffrey , COLLIER, Steven J. , SMITH, Derek , NAZOR, Jovana , HUGHES, Gregory , JANEY, Jacob , HUISMAN, Gjalt , NOVICK, Scott , AGARD, Nicholas , ALVIZO, Oscar , COPE, Gregory , YEO, Wan Lin , SUKUMARAN, Joly , MINOR, Stefanie, Ng
IPC分类号： C07K14/435
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
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