-
公开(公告)号：EP2847327B1
公开(公告)日：2018-12-26
申请号：EP13788385.6
申请日：2013-05-07
申请人： Codexis, Inc.
发明人： CHEN, Haibin , BONG, Yong Koy , CABIROL, Fabien , GOHEL, Anupam , LI, Tao , MOORE, Jeffrey C. , QUINTANAR-AUDELO, Martina , YANG, Hong , COLLIER, Steven, J. , SMITH, Derek
CPC分类号： C12P17/12 , C12N9/0071 , C12P13/04 , C12P13/24 , C12P17/188 , C12Y114/11002 , Y02P20/52
摘要： The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered proline hydroxylase biocatalysts, polynucleotides encoding the biocatalysts, methods of their preparation, and processes for preparing hydroxylated compounds using these engineered biocatalysts.
-
2.发明授权ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS 有权用于酮和胺化合物的还原胺化的工程化亚胺减少物和方法
公开(公告)号：EP2847214B1
公开(公告)日：2017-12-27
申请号：EP13724127.9
申请日：2013-05-09
申请人： Codexis, Inc.
发明人： CHEN, Haibin , MOORE, Jeffrey , COLLIER, Steven J. , SMITH, Derek , NAZOR, Jovana , HUGHES, Gregory , JANEY, Jacob , HUISMAN, Gjalt , NOVICK, Scott , AGARD, Nicholas , ALVIZO, Oscar , COPE, Gregory , YEO, Wan Lin , SUKUMARAN, Joly , MINOR, Stefanie, Ng
IPC分类号： C07K14/435
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
-
公开(公告)号：EP2847327A2
公开(公告)日：2015-03-18
申请号：EP13788385.6
申请日：2013-05-07
申请人： Codexis, Inc.
发明人： CHEN, Haibin , BONG, Yong Koy , CABIROL, Fabien , GOHEL, Anupam , LI, Tao , MOORE, Jeffrey C. , QUINTANAR-AUDELO, Martina , YANG, Hong , COLLIER, Steven, J. , SMITH, Derek
IPC分类号： C12N9/04
CPC分类号： C12P17/12 , C12N9/0071 , C12P13/04 , C12P13/24 , C12P17/188 , C12Y114/11002 , Y02P20/52
摘要： The present disclosure provides engineered proline hydroxylase polypeptides for the production of hydroxylated compounds, polynucleotides encoding the engineered proline hydroxylases, host cells capable of expressing the engineered proline hydroxylases, and methods of using the engineered proline hydroxylases to prepare compounds useful in the production of active pharmaceutical agents. The present disclosure provides engineered proline hydroxylase biocatalysts, polynucleotides encoding the biocatalysts, methods of their preparation, and processes for preparing hydroxylated compounds using these engineered biocatalysts.
摘要翻译： 本公开内容提供了用于产生羟基化化合物的工程化脯氨酸羟化酶多肽，编码工程化脯氨酸羟化酶的多核苷酸，能够表达工程化脯氨酸羟化酶的宿主细胞，以及使用工程化脯氨酸羟化酶制备可用于生产活性药物的化合物的方法 代理商。
-
公开(公告)号：EP2753640B1
公开(公告)日：2016-03-09
申请号：EP12769209.3
申请日：2012-09-07
申请人： Codexis, Inc.
发明人： CABIROL, Fabien, L. , CHEN, Haibin , GOHEL, Anupam , SALIM, Paulina , SMITH, Derek , JANEY, Jacob , KOSJEK, Birgit , TANG, Weng, Lin , HSIEH, Helen , PHAM, Son
IPC分类号： C07K14/435
CPC分类号： C12N9/1096 , C07D211/76 , C12P13/001 , C12P13/005 , C12P17/12 , C12Y206/01
摘要： The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.
-
5.发明公开ENGINEERED IMINE REDUCTASES AND METHODS FOR THE REDUCTIVE AMINATION OF KETONE AND AMINE COMPOUNDS 有权MANIPULIERTE IMINREDUKTASEN UND VERFAHREN ZUR REDUKTIVEN AMINIERUNG VON KETON- UND AMINVERBINDUNGEN
公开(公告)号：EP2847214A1
公开(公告)日：2015-03-18
申请号：EP13724127.9
申请日：2013-05-09
申请人： Codexis, Inc.
发明人： CHEN, Haibin , MOORE, Jeffrey , COLLIER, Steven J. , SMITH, Derek , NAZOR, Jovana , HUGHES, Gregory , JANEY, Jacob , HUISMAN, Gjalt , NOVICK, Scott , AGARD, Nicholas , ALVIZO, Oscar , COPE, Gregory , YEO, Wan Lin , SUKUMARAN, Joly , MINOR, Stefanie, Ng
IPC分类号： C07K14/435
CPC分类号： C12P13/02 , C12N9/0028 , C12P13/001 , C12P13/04 , C12P13/06 , C12P17/10 , C12P17/12 , C12P17/165 , C12P17/185 , C12P17/188 , C12Y105/01 , C12Y105/01023 , C12Y105/01024 , C12Y105/01028 , Y02P20/52
摘要： The present disclosure provides engineered polypeptides having imine reductase activity, polynucleotides encoding the engineered imine reductases, host cells capable of expressing the engineered imine reductases, and methods of using these engineered polypeptides with a range of ketone and amine substrate compounds to prepare secondary and tertiary amine product compounds.
摘要翻译： 本公开提供了具有亚胺还原酶活性的工程化多肽，编码工程改造的亚胺还原酶的多核苷酸，能够表达工程化亚胺还原酶的宿主细胞，以及使用这些工程改造的多肽与一系列酮和胺底物化合物以制备仲胺和叔胺的方法 产品化合物。
-
6.发明公开BIOCATALYSTS FOR THE PREPARATION OF HYDROXY SUBSTITUTED CARBAMATES 审中-公开BIOKATALYSATOREN ZUR HERSTELLUNG VON HYDROXYSUBSTITUIERTEN CARBAMATEN
公开(公告)号：EP2780448A1
公开(公告)日：2014-09-24
申请号：EP12795954.2
申请日：2012-11-14
申请人： Codexis, Inc.
发明人： CABIROL, Fabien , CHEN, Haibin , GOHEL, Anupam , COLLIER, Steven, J. , SMITH, Derek , KOSJEK, Birgit , JANEY, Jacob
CPC分类号： C12N9/0006 , C12N15/70 , C12P13/00 , C12P13/001 , C12P13/02 , C12P41/002 , C12Y101/01184 , Y02P20/52
摘要： The present disclosure relates to engineered ketoreductase polypeptides for the preparation of hydroxyl substituted carbamate compounds, and polynucleotides, vectors, host cells, and methods of making and using the ketoreductase polypeptides.
摘要翻译： 本公开涉及用于制备羟基取代的氨基甲酸酯化合物的工程化酮还原酶多肽，以及多核苷酸，载体，宿主细胞，以及制备和使用酮还原酶多肽的方法。
-
公开(公告)号：EP2753640A1
公开(公告)日：2014-07-16
申请号：EP12769209.3
申请日：2012-09-07
申请人： Codexis, Inc.
发明人： CABIROL, Fabien, L. , CHEN, Haibin , GOHEL, Anupam , SALIM, Paulina , SMITH, Derek , JANEY, Jacob , KOSJEK, Birgit , TANG, Weng, Lin , HSIEH, Helen , PHAM, Son
IPC分类号： C07K14/435
CPC分类号： C12N9/1096 , C07D211/76 , C12P13/001 , C12P13/005 , C12P17/12 , C12Y206/01
摘要： The present disclosure relates to transaminase polypeptides capable of aminating a dicarbonyl substrate, and polynucleotides, vectors, host cells, and methods of making and using the transaminase polypeptides.
-
-
-
-
-
-
搜索结果
7 条记录 (耗时 0.028 秒)
