发明公开
- 专利标题： NOVEL AMINE DERIVATIVE OR SALT THEREOF
- 专利标题（中）： NEUARTIGES AMINDERIVAT ODER SALZ DAVON
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申请号： EP13851612.5申请日： 2013-10-30
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公开(公告)号： EP2915804A1公开(公告)日： 2015-09-09
- 发明人: TANAKA, Tadashi , KONISHI, Yoshitake , KUBO, Daisuke , FUJINO, Masataka , DOI, Issei , NAKAGAWA, Daisuke , MURAKAMI, Tatsuya , YAMAKAWA, Takayuki
- 申请人： Toyama Chemical Co., Ltd. , FUJIFILM Corporation
- 申请人地址： 2-5 Nishishinjuku 3-Chome Shinjuku-ku Tokyo 160-0023 JP
- 专利权人： Toyama Chemical Co., Ltd.,FUJIFILM Corporation
- 当前专利权人： Toyama Chemical Co., Ltd.,FUJIFILM Corporation
- 当前专利权人地址： 2-5 Nishishinjuku 3-Chome Shinjuku-ku Tokyo 160-0023 JP
- 代理机构： Blodig, Wolfgang
- 优先权： JP2012240172 20121031; JP2013050845 20130313
- 国际公布： WO2014069510 20140508
- 主分类号： C07D209/08
- IPC分类号： C07D209/08 ; A61K31/4035 ; A61K31/404 ; A61K31/416 ; A61K31/4184 ; A61K31/423 ; A61K31/427 ; A61K31/428 ; A61K31/437 ; A61K31/4439 ; A61K31/454 ; A61K31/455 ; A61K31/4709 ; A61K31/4725 ; A61K31/497 ; A61K31/498 ; A61K31/501 ; A61K31/506 ; A61K31/517 ; A61K31/5377
摘要：
A novel amine derivative expressed by general formula (1)
(in the formula: G 1 , G 2 , and G 3 are the same or different and represent CH or a nitrogen atom; R 1 represents a chlorine atom, an optionally-substituted C 3-8 cycloalkyl group, or the like; R 2 represents -COOR 5 (in the formula, R 5 represents a hydrogen atom or a carboxyl protective group), or the like; R 3 represents a hydrogen atom, or the like; and R 4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.
(in the formula: G 1 , G 2 , and G 3 are the same or different and represent CH or a nitrogen atom; R 1 represents a chlorine atom, an optionally-substituted C 3-8 cycloalkyl group, or the like; R 2 represents -COOR 5 (in the formula, R 5 represents a hydrogen atom or a carboxyl protective group), or the like; R 3 represents a hydrogen atom, or the like; and R 4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.
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