公开(公告)号：EP2915804A1

公开(公告)日：2015-09-09

申请号：EP13851612.5

申请日：2013-10-30

申请人： Toyama Chemical Co., Ltd. ,  FUJIFILM Corporation

发明人： TANAKA, Tadashi ,  KONISHI, Yoshitake ,  KUBO, Daisuke ,  FUJINO, Masataka ,  DOI, Issei ,  NAKAGAWA, Daisuke ,  MURAKAMI, Tatsuya ,  YAMAKAWA, Takayuki

IPC分类号： C07D209/08 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377

CPC分类号： C07D471/04 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/538 ,  C07C211/45 ,  C07D209/04 ,  C07D209/08 ,  C07D209/12 ,  C07D209/34 ,  C07D209/38 ,  C07D209/42 ,  C07D209/46 ,  C07D209/48 ,  C07D213/80 ,  C07D215/227 ,  C07D215/38 ,  C07D217/24 ,  C07D231/56 ,  C07D235/08 ,  C07D235/26 ,  C07D239/88 ,  C07D241/44 ,  C07D263/58 ,  C07D265/36 ,  C07D277/68 ,  C07D401/04 ,  C07D401/06 ,  C07D401/10 ,  C07D401/12 ,  C07D401/14 ,  C07D403/04 ,  C07D403/12 ,  C07D405/14 ,  C07D407/14 ,  C07D413/06 ,  C07D413/10 ,  C07D413/12 ,  C07D413/14 ,  C07D417/04 ,  C07D417/06 ,  C07D417/12 ,  Y02P20/55

摘要： A novel amine derivative expressed by general formula (1)

(in the formula: G 1 , G 2 , and G 3 are the same or different and represent CH or a nitrogen atom; R 1 represents a chlorine atom, an optionally-substituted C 3-8 cycloalkyl group, or the like; R 2 represents -COOR 5 (in the formula, R 5 represents a hydrogen atom or a carboxyl protective group), or the like; R 3 represents a hydrogen atom, or the like; and R 4 represents an optionally-substituted condensed bicyclic hydrocarbon group, an optionally-substituted bicyclic heterocyclic group, or the like), or a salt thereof is useful in procedures such as the treatment or prevention of conditions related to excessive keratinocyte proliferation.

摘要翻译： 由通式（1）表示的新型胺衍生物（式中，G 1，G 2和G 3相同或不同，表示CH或氮原子; R 1表示氯原子，任意取代的C 3-8环烷基等; R 2表示-COOR 5（式中，R 5表示氢原子或羧基保护基）等; R 3表示氢原子等;以及 R 4表示任选取代的稠合双环烃基，任选取代的双环杂环基等）或其盐可用于治疗或预防与过度角质形成细胞增殖相关的病症的过程。

公开(公告)号：EP2915804B1

公开(公告)日：2019-03-27

申请号：EP13851612.5

申请日：2013-10-30

申请人： FUJIFILM Toyama Chemical Co., Ltd. ,  FUJIFILM Corporation

发明人： TANAKA, Tadashi ,  KONISHI, Yoshitake ,  KUBO, Daisuke ,  FUJINO, Masataka ,  DOI, Issei ,  NAKAGAWA, Daisuke ,  MURAKAMI, Tatsuya ,  YAMAKAWA, Takayuki

IPC分类号： C07D209/08 ,  A61K31/4035 ,  A61K31/404 ,  A61K31/416 ,  A61K31/4184 ,  A61K31/423 ,  A61K31/427 ,  A61K31/428 ,  A61K31/437 ,  A61K31/4439 ,  A61K31/454 ,  A61K31/455 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/497 ,  A61K31/498 ,  A61K31/501 ,  A61K31/506 ,  A61K31/517 ,  A61K31/5377

公开(公告)号：EP2727920B1

公开(公告)日：2016-11-02

申请号：EP12819498.2

申请日：2012-07-27

申请人： FUJIFILM Corporation

发明人： FURUYAMA, Hidetomo ,  KURIHARA, Hideki ,  FURUYA, Kentarou ,  TERAO, Takahiro ,  SEKINE, Shinichirou ,  NAKAGAWA, Daisuke

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61P5/00 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61K31/4375 ,  C07D519/00 ,  C07F7/10

公开(公告)号：EP4446331A1

公开(公告)日：2024-10-16

申请号：EP22904284.1

申请日：2022-12-08

申请人： FUJIFILM Corporation

发明人： NAKAGAWA, Daisuke ,  TSUYAMA, Hiroaki ,  YOSHIDA, Hayato ,  MOGI, Takuma

IPC分类号： C07K1/06 ,  C07C43/23 ,  C07C69/712 ,  C07C235/06 ,  C07C271/16

摘要： An object of the present invention is to provide a method for producing a peptide compound with an excellent yield, a protective group-forming reagent having an excellent yield, and a novel substituted benzyl compound. According to the present invention, there is provided a method for producing a peptide compound, including a step of using a substituted benzyl compound represented by Formula (1).

In Formula (1), Y represents -OH, -NHR, -SH, or -X, R represents a hydrogen atom, an alkyl group, an arylalkyl group, a heteroarylalkyl group, or a 9-fluorenylmethoxycarbonyl group, X represents Cl, Br, or I, m represents 1 or 2, n represents an integer of 1 to 5, R B 's each independently represent an aliphatic hydrocarbon group, R A 's each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, where the number of carbon atoms in at least one aliphatic hydrocarbon group is 12 or more, and a benzene ring in Formula (1) may further have a substituent in addition to R A .

公开(公告)号：EP3275883A1

公开(公告)日：2018-01-31

申请号：EP16768957.9

申请日：2016-03-25

申请人： FUJIFILM Corporation

发明人： FUKUNAGA, Hirofumi ,  SHINJO, Sachiko ,  NAKAGAWA, Daisuke ,  SEKINE, Shinichiro ,  YAMAKAWA, Takayuki

IPC分类号： C07D471/04 ,  A61K31/395 ,  A61K31/555 ,  A61K51/00 ,  A61P35/00 ,  A61P43/00 ,  C07B59/00 ,  C07D255/02 ,  C07D257/02 ,  C07F1/08 ,  C07F5/00

CPC分类号： A61K31/4375 ,  A61K31/145 ,  A61K31/223 ,  A61K31/27 ,  A61K31/395 ,  A61K31/555 ,  A61K31/785 ,  A61K51/00 ,  C07B59/00 ,  C07D255/02 ,  C07D257/02 ,  C07D471/04 ,  C07D487/00 ,  C07F1/08 ,  C07F5/00

摘要： Provided are a method for efficiently manufacturing a nitrogen-containing compound, which is used for manufacturing a treatment agent for integrin-related diseases, or a salt thereof and a manufacturing intermediate of the compound or a salt thereof.
A method for manufacturing a novel nitrogen-containing compound or a salt thereof includes (1) a step of obtaining a compound represented by Formula [10] or a salt thereof through an amidation reaction; and (2) a step of deprotecting the compound represented by Formula [10] or a salt thereof.

摘要翻译： 本发明提供一种有效地制造用于制造整联蛋白相关疾病治疗剂的含氮化合物或其盐以及该化合物或其盐的制造中间体的方法。 用于制造新的含氮化合物或其盐的方法包括（1）通过酰胺化反应获得式[10]表示的化合物或其盐的步骤; 和（2）将式[10]代表的化合物或其盐脱保护的步骤。

公开(公告)号：EP2727920A1

公开(公告)日：2014-05-07

申请号：EP12819498.2

申请日：2012-07-27

申请人： FUJIFILM Corporation

发明人： FURUYAMA, Hidetomo ,  KURIHARA, Hideki ,  FURUYA, Kentarou ,  TERAO, Takahiro ,  SEKINE, Shinichirou ,  NAKAGAWA, Daisuke

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4709 ,  A61K31/496 ,  A61K31/5377 ,  A61P5/00 ,  A61P9/00 ,  A61P25/00 ,  A61P29/00 ,  A61P31/00 ,  A61P35/00 ,  A61P37/06 ,  A61P37/08 ,  A61P43/00 ,  C07D519/00

CPC分类号： C07D471/04 ,  A61K31/4375 ,  C07D519/00 ,  C07F7/10

摘要： A 1,5-naphthyridine derivative represented by Formula [1] (in which R 1 , R 2 , R 3 , R 4 and R 5 represent a hydrogen atom, -L-Z (in which Z represents a non-aromatic heterocyclic group or the like; and L represents a single bond or the like), or the like, R 6 represents -L-Z or the like, R 7 and R 8 represent a hydrogen atom or the like, and Q represents an oxygen atom or the like), or a salt thereof has an excellent inhibitory activity with respect to the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway, and is useful for treatments such as prophylactic treatments and therapeutic treatments of diseases in which the PI3K-AKT pathway and the Ras-Raf-MEK-ERK pathway are involved.

摘要翻译： 由式[1]表示的1,5-萘啶衍生物（其中R 1，R 2，R 3，R 4和R 5表示氢原子，-LZ（其中Z表示非芳香族杂环基或 类似，L表示单键等）等，R 6表示-LZ等，R 7和R 8表示氢原子等，Q表示氧原子等）， 或其盐对PI3K-AKT途径和Ras-Raf-MEK-ERK途径具有优异的抑制活性，并且可用于诸如预防性治疗和PI3K-AKT途径和 涉及Ras-Raf-MEK-ERK途径。

公开(公告)号：EP3932899A1

公开(公告)日：2022-01-05

申请号：EP20763669.7

申请日：2020-02-25

申请人： FUJIFILM Corporation

发明人： YAMAMOTO, Yosuke ,  KANEKO, Kazuhei ,  TAKAHASHI, Motomasa ,  TAKAHASHI, Makoto ,  IMAMURA, Mika ,  SATOU, Hirotaka ,  OMURA, Hirofumi ,  YOSHIMITSU, Yuji ,  NAKAGAWA, Daisuke ,  TANAKA, Keita

IPC分类号： C07C43/23 ,  C07K1/06

摘要： Provided are a method for producing a peptide compound including a step of using a condensed polycyclic aromatic hydrocarbon compound represented by Formula (1); a protective group-forming reagent including the compound; and the compound. In Formula (1), a ring A represents a condensed polycyclic aromatic hydrocarbon ring, Y A 's each independently represent -CH 2 OH, -CH 2 NHR, -CH 2 SH, or -CH 2 X 0 , where R represents a hydrogen atom, an alkyl group, or an aralkyl group, and X 0 represents Cl, Br, or I, k represents an integer of 1 to 5, n represents 1 or 2, and R A 's each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group.

公开(公告)号：EP4059936A1

公开(公告)日：2022-09-21

申请号：EP22170836.5

申请日：2016-03-25

申请人： FUJIFILM Corporation

发明人： FUKUNAGA, Hirofumi ,  SHINJO, Sachiko ,  NAKAGAWA, Daisuke ,  SEKINE, Shinichiro ,  YAMAKAWA, Takayuki

IPC分类号： C07F5/00 ,  A61K31/395 ,  A61K31/555 ,  A61K51/00 ,  A61P35/00 ,  A61P43/00 ,  C07B59/00 ,  C07D255/02 ,  C07D257/02 ,  C07F1/08

摘要： Provided are a method for efficiently manufacturing a nitrogen-containing compound, which is used for manufacturing a treatment agent for integrin-related diseases, or a salt thereof and a manufacturing intermediate of the compound or a salt thereof.
A method for manufacturing a novel nitrogen-containing compound or a salt thereof includes (1) a step of obtaining a compound represented by Formula [10] or a salt thereof through an amidation reaction; and (2) a step of deprotecting the compound represented by Formula [10] or a salt thereof.

公开(公告)号：EP3916000A1

公开(公告)日：2021-12-01

申请号：EP20763894.1

申请日：2020-02-25

申请人： FUJIFILM Corporation

发明人： YAMAMOTO, Yosuke ,  KANEKO, Kazuhei ,  TAKAHASHI, Motomasa ,  TAKAHASHI, Makoto ,  IMAMURA, Mika ,  SATOU, Hirotaka ,  OMURA, Hirofumi ,  YOSHIMITSU, Yuji ,  TANAKA, Keita ,  NAKAGAWA, Daisuke

IPC分类号： C07K1/02 ,  C07K1/06

摘要： Provided are a method for producing a peptide compound including a step of using an aromatic heterocyclic compound represented by Formula (1) represented by Formula (1); a protective group-forming reagent including the compound; and the compound. In Formula (1), a ring A represents an aromatic heterocyclic ring, Y A 's each independently represent -OH, -NHR, -SH, or -X 0 , where X 0 represents Cl, Br, or I, R A and R C each independently represent an aliphatic hydrocarbon group or an organic group having an aliphatic hydrocarbon group, R B s' each independently represent a monovalent aliphatic hydrocarbon group, a (1+c)-valent aromatic group, or a (1+c)-valentheteroaromatic group, where, in a case where both a and c is 0, R B is a monovalent aliphatic hydrocarbon group, and the number of carbon atoms in at least one aliphatic hydrocarbon group of R A , R B , or R C is 12 or more.

公开(公告)号：EP2944637B1

公开(公告)日：2020-02-19

申请号：EP14737606.5

申请日：2014-01-14

申请人： FUJIFILM Corporation

发明人： FURUYAMA, Hidetomo ,  KURIHARA, Hideki ,  TERAO, Takahiro ,  NAKAGAWA, Daisuke ,  TANABE, Shintaro ,  KATO, Takayuki ,  YAMAMOTO, Masahiko ,  SEKINE, Shinichiro ,  MASHIKO, Tomoyuki ,  INUKI, Shinsuke ,  UEDA, Satoshi

IPC分类号： C07D471/04 ,  A61K31/4375 ,  A61K31/444 ,  A61K31/4545 ,  A61K31/4709 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/497 ,  A61K31/4985 ,  A61K31/501 ,  A61K31/5025 ,  A61K31/506 ,  A61K31/5377 ,  A61K31/551 ,  A61P3/00 ,  A61P5/00 ,  A61P9/00 ,  A61P25/28 ,  A61P29/00