A novel α-halogen-substituted thiophene compound or a pharmacologically acceptable salt thereof, which has a potent LPA receptor-antagonist activity and is useful as a medicament is provided.
A compound represented by the general formula (I) wherein A represents, a phenyl ring, a thiophene ring, or an isothiazole ring; R 1 is the same or different, and represents a halogen atom, or a C 1 -C 3 alkyl group; R 2 represents a hydrogen atom, or a C 1 -C 6 alkyl group; p represents an integer of 0 to 5; V represents CR 3 wherein R 3 represents a hydrogen atom, an amino group, a nitro group, or a C 1 -C 3 alkoxy group, or V represents a nitrogen atom; and X represents a halogen atom, or a salt thereof.