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    PYRROLOPYRIDAZINONE COMPOUND
    9.
    发明公开
    PYRROLOPYRIDAZINONE COMPOUND 有权
    吡咯并哒嗪酮化合物

    公开(公告)号：EP1982986A1

    公开(公告)日：2008-10-22

    申请号：EP07706860.9

    申请日：2007-01-16

    申请人： Ube Industries, Ltd.

    发明人： HAGIHARA, Masahiko ,  TANAKA, Masayuki ,  KATSUBE, Tetsushi ,  OKUDO, Makoto ,  IWASE, Noriaki ,  SHIGETOMI, Manabu ,  KANDA, Tomoko ,  NAKANISHI, Takayuki

    IPC分类号： C07D487/04 ,  A61K31/5025 ,  A61P1/00 ,  A61P1/18 ,  A61P9/00 ,  A61P11/00 ,  A61P13/12 ,  A61P29/00 ,  A61P31/00 ,  A61P43/00

    CPC分类号： C07D487/04

    摘要： The present invention discloses a pyrrolopyridazinone compound represented by the formula (1):

    wherein R 1 represents C 1 -C 2 alkyl group or halogeno C 1 -C 2 alkyl group,
    R 2 repersents C 3 -C 5 cycloalkyl group, (C 3 -C 5 cycloalkyl)C 1 -C 2 alkyl group or C 1 -C 3 alkyl group,
    R 3 represents hydrogen atom, or methylene group or cis-vinylene group for forming substituted oxygen-containing hetero ring in combination with group -O-R 2 ,
    R 4 represents hydrogen atom, halogen atom, C 1 -C 8 alkyl group, C 2 -C 6 alkenyl group, C 2 -C 6 alkynyl group, hydroxy C 3 -C 6 alkenyl group, hydroxy C 3 -C 6 alkynyl group, C 1 -C 6 alkyl group substituted by substituent(s) selected from Substituent group (a), C 3 -C 6 cycloalkyl group which may be substituted by substituent(s) selected from Substituent group (b), "C 1 -C 3 alkyl group which is substituted by C 3 -C 6 cycloalkyl group which may be substituted by substituent(s) selected from Substituent group (b), and which may be substituted by a hydroxy group", an aromatic ring group or heteroaromatic ring group each of which may be substituted by a substituent(s) selected from Substituent group (c) or "C 1 -C 2 alkyl group which is substituted by aromatic ring group or heteroaromatic ring group each of which may be substituted by group(s) selected from Substituent group (c), and which may be substituted by a hydroxy group",
    Substituent group (a) represents a halogen atom, hydroxy group, cyano group, carboxy group, C 1 -C 5 alkoxy group, halogeno C 1 -C 4 alkoxy group, C 3 -C 6 cycloalkoxy group, (C 3 -C 6 cycloalkyl) C 1 -C 2 alkoxy group, C 1 -C 4 alkoxycarbonyl group, C 2 -C 4 alkanoyl group, C 2 -C 4 alkanoyloxy group or C 1 -C 4 alkyl-substituted amino group,
    Substituent group (b) represents a hydroxy group or a halogen atom,
    Substituent group (c) represents a halogen atom, a hydroxy group, a cyano group, a nitro group, a carboxy group, C 1 -C 5 alkoxy group, C 1 -C 4 alkoxycarbonyl group, C 2 -C 4 alkanoyloxy group, C 1 -C 4 alkyl-substituted amino group or a C 1 -C 4 alkyl group which may be substituted by a substituent(s) selected from the group consisting of (a halogen atom, a hydroxy group and a carboxy group),
    or a pharmaceutically acceptable salt thereof.

    摘要翻译： 本发明公开了由式（1）表示的吡咯并哒嗪酮化合物：其中R 1表示C 1 -C 2烷基或卤代C 1 -C 2烷基，R 2取代基C 3 -C 5环烷基，（C 3 -C 5环烷基）C 1 -C 2烷基 或C1-C3烷基，R3表示氢原子或用于与-O-R2基团结合形成取代的含氧杂环的亚甲基或顺式 - 亚乙烯基，R4表示氢原子，卤素原子，C1-C8烷基 ，C2-C6烯基，C2-C6炔基，羟基C3-C6烯基，羟基C3-C6炔基，被选自取代基组（a）的取代基取代的C1-C6烷基，C3- 可被选自取代基组（b）的取代基取代的“可被选自取代基组（b）的取代基取代的C3-C6环烷基取代的C1-C3烷基， 并且其可以被羟基取代“，芳族环基团或杂芳族基团 可以被选自取代基组（c）中的取代基取代的芳基环基团或被可被基团（s）取代的芳香环基团或杂芳香环基团取代的C1-C2烷基基团 （a）中选自取代基组（c）的，可被羟基取代的取代基“），取代基组（a）表示卤素原子，羟基，氰基，羧基，C1〜C5烷氧基，卤代C1〜C4烷氧基 （C 3 -C 6环烷基）C 1 -C 2烷氧基，C 1 -C 4烷氧基羰基，C 2 -C 4烷酰基，C 2 -C 4烷酰氧基或C 1 -C 4烷基取代的氨基，取代基组（C 3 -C 6环烷氧基） b）表示羟基或卤素原子，取代基组（c）表示卤原子，羟基，氰基，硝基，羧基，C1-C5烷氧基，C1-C4烷氧基羰基，C2 -C4烷酰氧基，C1-C4烷基取代的氨基或可以被取代的C1-C4烷基 选自（卤原子，羟基和羧基）的化合物或其药学上可接受的盐。