- 专利标题: INHIBITORS OF BRUTON'S TYROSINE KINASE
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申请号: EP14809642.3申请日: 2014-12-10
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公开(公告)号: EP3080097B1公开(公告)日: 2018-04-18
- 发明人: LOPEZ-TAPIA, Francisco Javier , SO, Sung-Sau , QIAO, Qi , DOMINIQUE, Romyr
- 申请人: F. Hoffmann-La Roche AG
- 申请人地址: Grenzacherstrasse 124 4070 Basel CH
- 专利权人: F. Hoffmann-La Roche AG
- 当前专利权人: F. Hoffmann-La Roche AG
- 当前专利权人地址: Grenzacherstrasse 124 4070 Basel CH
- 代理机构: Sauer, Frank
- 优先权: US201361915576P 20131213
- 国际公布: WO2015086635 20150618
- 主分类号: C07D401/14
- IPC分类号: C07D401/14 ; C07D403/06 ; C07D403/14 ; C07D409/14 ; A61K31/4155 ; A61K31/4439 ; A61P29/00 ; A61P11/06
摘要:
This application discloses compounds according to generic Formula (I): wherein all variables are defined as described herein, which inhibit Btk. The compounds disclosed herein are useful to modulate the activity of Btk and treat diseases associated with excessive Btk activity. The compounds are useful for the treatment of oncological, auto-immune, and inflammatory diseases caused by aberrant B-cell activation. Also disclosed are compositions containing compounds of Formula (I) and at least one carrier, diluent or excipient.
公开/授权文献
- EP3080097A1 INHIBITORS OF BRUTON'S TYROSINE KINASE 公开/授权日:2016-10-19
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