- 专利标题： THERAPY REGIMEN AND METHODS TO SENSITIZE CANCER CELLS TREATED WITH EPIGENETIC THERAPY TO PARP INHIBITORS IN MULTIPLE CANCERS
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申请号： EP15740207申请日： 2015-01-21
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公开(公告)号： EP3102199A4公开(公告)日： 2018-01-17
- 发明人: RASSOOL FEYRUZ , BAYLIN STEPHEN , ROBERT CARINE
- 申请人： UNIV JOHNS HOPKINS , UNIV MARYLAND
- 专利权人： UNIV JOHNS HOPKINS,UNIV MARYLAND
- 当前专利权人： UNIV JOHNS HOPKINS,UNIV MARYLAND
- 优先权： US201461929680 2014-01-21
- 主分类号： A61K31/341
- IPC分类号： A61K31/341 ; A61K31/4184 ; A61K31/7068 ; A61P35/00
摘要：
The presently disclosed subject matter provides methods to treat cancer cells using low doses of DNA demethylating agents and poly ADP ribose polymerase (PARP) inhibitors. Methods also are provided for sensitizing a cell to a PARP inhibitor.
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