发明公开
EP3146066A1 COMPOSITIONS AND METHODS FOR STABILIZING LUMINOGENIC SUBSTRATES
有权
ZUSAMMENSETZUNGEN UND VERFAHREN ZUR STABILISIERUNG VON LUMINOGENEN SUBSTRATEN
- 专利标题： COMPOSITIONS AND METHODS FOR STABILIZING LUMINOGENIC SUBSTRATES
- 专利标题（中）： ZUSAMMENSETZUNGEN UND VERFAHREN ZUR STABILISIERUNG VON LUMINOGENEN SUBSTRATEN
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申请号： EP15730321.5申请日： 2015-05-26
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公开(公告)号： EP3146066A1公开(公告)日： 2017-03-29
- 发明人: KIRKLAND, Thomas , WOOD, Keith, V. , HALL, Mary , SCHWINN, Marie
- 申请人： Promega Corporation
- 申请人地址： 2800 Woods Hollow Road Madison, WI 53711-5399 US
- 专利权人： Promega Corporation
- 当前专利权人： Promega Corporation
- 当前专利权人地址： 2800 Woods Hollow Road Madison, WI 53711-5399 US
- 代理机构： Potter Clarkson LLP
- 优先权： US201462002363P 20140523
- 国际公布： WO2015179864 20151126
- 主分类号： C12Q1/66
- IPC分类号： C12Q1/66 ; C07D253/06
摘要：
Disclosed herein are compositions and methods for stabilizing a luminogenic substrate such as coelenterazine or a functional analog thereof. The functional analog may be furimazine. The composition may include the luminogenic substrate, a thionucleoside, and an organic solvent, in which the thionucleoside is present in an amount effective to stabilize the luminogenic composition against decomposition. The method provided herein stabilizes the luminogenic substrate against decomposition by contacting the luminogenic substrate with an effective amount of the thionucleoside in the presence of the organic solvent. Also provided herein is a kit containing the composition.
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