-
公开(公告)号：EP3562823A1
公开(公告)日：2019-11-06
申请号：EP17832700.3
申请日：2017-12-28
申请人： Promega Corporation
发明人： FLEMMING, Roderick, G. , HALL, Mary , MACHLEIDT, Thomas , MEISENHEIMER, Poncho , NATH, Nidhi , ROBERS, Matthew B. , WALKER, Joel R. , ZHOU, Wenhui
IPC分类号： C07D403/12 , C07D417/14 , C07D495/04 , C07D209/12 , C07D519/00 , G01N33/58 , C12Q1/66
-
公开(公告)号：EP3146066B1
公开(公告)日：2018-03-14
申请号：EP15730321.5
申请日：2015-05-26
申请人： Promega Corporation
发明人： KIRKLAND, Thomas , WOOD, Keith, V. , HALL, Mary , SCHWINN, Marie
IPC分类号： C12Q1/66 , C07D253/06
CPC分类号： C09K11/06 , A61K31/4985 , A61K31/53 , C07D253/075 , C07D487/04 , C09K2211/1007 , C09K2211/1044 , C12Q1/66
摘要： Disclosed herein are compositions and methods for stabilizing a luminogenic substrate such as coelenterazine or a functional analog thereof. The functional analog may be furimazine. The composition may include the luminogenic substrate, a thionucleoside, and an organic solvent, in which the thionucleoside is present in an amount effective to stabilize the luminogenic composition against decomposition. The method provided herein stabilizes the luminogenic substrate against decomposition by contacting the luminogenic substrate with an effective amount of the thionucleoside in the presence of the organic solvent. Also provided herein is a kit containing the composition.
-
公开(公告)号：EP2456864A1
公开(公告)日：2012-05-30
申请号：EP10717013.6
申请日：2010-05-03
申请人： Promega Corporation
发明人： ENCELL, Lance, P. , WOOD, Keith, V. , WOOD, Monika, G. , HALL, Mary , OTTO, Paul , VIDUGIRIS, Gediminas , ZIMMERMAN, Kristopher
CPC分类号： C12Q1/66 , C12N9/0004
摘要： The present invention discloses a modified luciferase polypeptide. The modified luciferase polypeptide has at least 60% amino acid sequence identity to a wild-type Oplophorus luciferase and includes at least one amino acid substitution at a position corresponding to an amino acid in a wild-type Oplophorus luciferase of SEQ ID NO: 1. The modified luciferase polypeptide has at least one of enhanced luminescence, enhanced signal stability, and enhanced protein stability relative to the wild-type Oplophorus luciferase.
-
公开(公告)号：EP3953374A1
公开(公告)日：2022-02-16
申请号：EP20788198.8
申请日：2020-04-10
申请人： Promega Corporation
发明人： KIRKLAND, Thomas , DART, Melanie , ZENG, Zhiyang , SMITH, Thomas , WOOD, Keith , MACHLEIDT, Thomas , JOST, Emily , KINCAID, Virginia , WANG, Hui , ZHOU, Wenhui , ENCELL, Lance , HALL, Mary , HURST, Robin
IPC分类号： C07K14/435 , C12N9/02 , C07K7/08 , G01N33/542 , C12Q1/66 , A61J1/20
-
公开(公告)号：EP3802514A1
公开(公告)日：2021-04-14
申请号：EP19731541.9
申请日：2019-05-31
申请人： Promega Corporation
IPC分类号： C07D333/38 , C07D333/66 , C07D333/68 , C07D333/78 , C07C311/21 , C12Q1/66
-
公开(公告)号：EP3548492A1
公开(公告)日：2019-10-09
申请号：EP17829356.9
申请日：2017-12-01
申请人： Promega Corporation
发明人： HALL, Mary , KIRKLAND, Thomas , MEISENHEIMER, Poncho , OHANA, Rachel, Friedman , SHAKHMIN, Anton , WALKER, Joel, R. , ZHOU, Wenhui
IPC分类号： C07D487/04 , C12Q1/66 , A61K31/4985
-
公开(公告)号：EP2635595B1
公开(公告)日：2019-01-09
申请号：EP11785534.6
申请日：2011-11-02
申请人： Promega Corporation
发明人： BINKOWSKI, Brock , ENCELL, Lance, P. , HALL, Mary , ROBERS, Matthew, B. , SLATER, Michael, R. , WOOD, Keith, V. , WOOD, Monika, G. , KLAUBERT, Dieter , MEISENHEIMER, Poncho , UNCH, James , VALLEY, Michael P.
IPC分类号： C07K14/435
-
公开(公告)号：EP4279490A3
公开(公告)日：2024-04-10
申请号：EP23175129.8
申请日：2017-12-01
申请人： Promega Corporation
发明人： HALL, Mary , KIRKLAND, Thomas , MEISENHEIMER, Poncho , OHANA, Rachel Friedman , SHAKHMIN, Anton , WALKER, Joel R. , ZHOU, Wenhui
IPC分类号： C07D487/04 , C12Q1/66 , A61K31/4985
摘要： Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
-
公开(公告)号：EP3807419A2
公开(公告)日：2021-04-21
申请号：EP19820498.4
申请日：2019-06-12
申请人： Promega Corporation
发明人： HALL, Mary , ENCELL, Lance P. , KILLORAN, Michael , WOOD, Keith , SMITH, Thomas , KINCAID, Virginia , KIRKLAND, Thomas , DART, Melanie
IPC分类号： C12Q1/68
-
公开(公告)号：EP3802853A1
公开(公告)日：2021-04-14
申请号：EP19732828.9
申请日：2019-06-05
申请人： Promega Corporation
发明人： KILLORAN, Michael , SHI, Ce , HALL, Mary , ENCELL, Lance P. , KIRKLAND, Thomas
-
-
-
-
-
-
-
-
-
搜索结果
21 条记录 (耗时 0.016 秒)
