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公开(公告)号：EP3941195A1
公开(公告)日：2022-01-26
申请号：EP20773701.6
申请日：2020-03-20
申请人： PROMEGA CORPORATION
IPC分类号： A01K67/027 , A61K38/00 , A61K38/46 , A61K49/00
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公开(公告)号：EP3146066B1
公开(公告)日：2018-03-14
申请号：EP15730321.5
申请日：2015-05-26
申请人： Promega Corporation
发明人： KIRKLAND, Thomas , WOOD, Keith, V. , HALL, Mary , SCHWINN, Marie
IPC分类号： C12Q1/66 , C07D253/06
CPC分类号： C09K11/06 , A61K31/4985 , A61K31/53 , C07D253/075 , C07D487/04 , C09K2211/1007 , C09K2211/1044 , C12Q1/66
摘要： Disclosed herein are compositions and methods for stabilizing a luminogenic substrate such as coelenterazine or a functional analog thereof. The functional analog may be furimazine. The composition may include the luminogenic substrate, a thionucleoside, and an organic solvent, in which the thionucleoside is present in an amount effective to stabilize the luminogenic composition against decomposition. The method provided herein stabilizes the luminogenic substrate against decomposition by contacting the luminogenic substrate with an effective amount of the thionucleoside in the presence of the organic solvent. Also provided herein is a kit containing the composition.
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公开(公告)号：EP4279490A2
公开(公告)日：2023-11-22
申请号：EP23175129.8
申请日：2017-12-01
申请人： Promega Corporation
发明人： HALL, Mary , KIRKLAND, Thomas , MEISENHEIMER, Poncho , OHANA, Rachel Friedman , SHAKHMIN, Anton , WALKER, Joel R. , ZHOU, Wenhui
IPC分类号： C07D487/04 , C12Q1/66 , A61K31/4985
摘要： Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
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公开(公告)号：EP3783011A1
公开(公告)日：2021-02-24
申请号：EP20197758.4
申请日：2014-03-13
申请人： Promega Corporation
发明人： DIXON, Andrew S. , ENCELL, Lance P. , HALL, Mary P. , WOOD, Keith V. , WOOD, Monika G. , SCHWINN, Marie , BINKOWSKI, Brock , ZEGZOUTI, Hicham , NATH, Nidhi , MONDAL, Subhanjan , GOUELI, Said , MEISENHEIMER, Poncho , KIRKLAND, Thomas , UNCH, James , PULUKKUNAT, Dileep K. , ROBERS, Matthew B. , DART, Melanie , MACHLEIDT, Thomas
IPC分类号： C07K14/435 , G01N33/50
摘要： Provided herein are compositions and methods for the assembly of a bioluminescent complex from two or more non-luminescent (e.g., substantially non-luminescent) peptide and/or polypeptide units. In particular, bioluminescent activity is conferred upon a non-luminescent polypeptide via structural complementation with another, complementary non-luminescent peptide.
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公开(公告)号：EP3454981A1
公开(公告)日：2019-03-20
申请号：EP17796767.6
申请日：2017-05-10
申请人： Promega Corporation
IPC分类号： B01J23/44 , B01J31/24 , B01J31/28 , C07B63/04 , C07D209/08 , C07D403/04 , C07D519/06
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公开(公告)号：EP3416968A1
公开(公告)日：2018-12-26
申请号：EP17706387.2
申请日：2017-02-14
申请人： Promega Corporation
发明人： SHAKHMIN, Anton , KIRKLAND, Thomas , WALKER, Joel , MACHLEIDT, Thomas , HALL, Mary , WOOD, Keith, V.
IPC分类号： C07D487/04 , A61K49/00 , C12Q1/66 , G01N21/76
CPC分类号： C12Q1/66 , A61K49/0013 , C07D487/04 , C07D519/00 , G01N33/581 , G01N2333/90241 , H04N1/6041
摘要： Described are coelenterazine analogues, methods for making the analogues, kits comprising the analogues, and methods of using the compounds for the detection of luminescence in luciferase-based assays.
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公开(公告)号：EP2931305B1
公开(公告)日：2018-11-28
申请号：EP13862430.9
申请日：2013-12-12
申请人： Promega Corporation
发明人： HITKO, Carolyn W. , HURST, Robin , KIRKLAND, Thomas , KLAUBERT, Dieter , MEISENHEIMER, Poncho , NATH, Nidhi , OHANA, Rachel F. , OTTO, Paul , URH, Marjeta , UYEDA, Harry Tetsuo , WOOD, Keith
IPC分类号： A61K39/00 , G01N33/543
CPC分类号： G01N33/54333 , G01N33/54306 , G01N33/54326
摘要： The present invention provides compositions and methods for capture and identification of the cellular targets of a bioactive agent. In particular, provided herein are bioactive agents tethered to capture ligand, cellular targets (optionally tagged with a reporter), capture proteins (optionally present as capture fusions), surfaces (e.g., displaying, capture ligands, capture proteins, or capture fusions), and methods of capturing and identifying the cellular targets of a bioactive agent therewith.
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公开(公告)号：EP3953374A1
公开(公告)日：2022-02-16
申请号：EP20788198.8
申请日：2020-04-10
申请人： Promega Corporation
发明人： KIRKLAND, Thomas , DART, Melanie , ZENG, Zhiyang , SMITH, Thomas , WOOD, Keith , MACHLEIDT, Thomas , JOST, Emily , KINCAID, Virginia , WANG, Hui , ZHOU, Wenhui , ENCELL, Lance , HALL, Mary , HURST, Robin
IPC分类号： C07K14/435 , C12N9/02 , C07K7/08 , G01N33/542 , C12Q1/66 , A61J1/20
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9.发明公开
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公开(公告)号：EP3548492A1
公开(公告)日：2019-10-09
申请号：EP17829356.9
申请日：2017-12-01
申请人： Promega Corporation
发明人： HALL, Mary , KIRKLAND, Thomas , MEISENHEIMER, Poncho , OHANA, Rachel, Friedman , SHAKHMIN, Anton , WALKER, Joel, R. , ZHOU, Wenhui
IPC分类号： C07D487/04 , C12Q1/66 , A61K31/4985
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