发明公开
EP3191113A1 MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80 (B7-1)/PD-LI PROTEIN/PROTEIN INTERACTIONS
审中-公开
大鼠PD-1 / PD-L1和CD80（B7-1）/ PD-LI蛋白/蛋白质相互作用的抑制剂
- 专利标题： MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80 (B7-1)/PD-LI PROTEIN/PROTEIN INTERACTIONS
- 专利标题（中）： 大鼠PD-1 / PD-L1和CD80（B7-1）/ PD-LI蛋白/蛋白质相互作用的抑制剂
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申请号： EP14776949.1申请日： 2014-09-11
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公开(公告)号： EP3191113A1公开(公告)日： 2017-07-19
- 发明人: MILLER, Michael Matthew , MAPELLI, Claudio , ALLEN, Martin Patrick , BOWSHER, Michael S. , GILLIS, Eric P. , LANGLEY, David R. , MULL, Eric , POIRIER, Maude A. , SANGHVI, Nishith , SUN, Li-Qiang , TENNEY, Daniel J. , YEUNG, Kap-Sun , ZHU, Juliang , GILLMAN, Kevin W. , ZHAO, Qian , GRANT-YOUNG, Katharine A. , SCOLA, Paul Michael , CORNELIUS, Lyndon, A., M.
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： Route 206 and Province Line Road Princeton, NJ 08543 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： Route 206 and Province Line Road Princeton, NJ 08543 US
- 代理机构： Kling, Edouard
- 国际公布： WO2016039749 20160317
- 主分类号： A61K38/10
- IPC分类号： A61K38/10 ; C07K7/08 ; G01N33/574
摘要：
The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
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