专利检索 ap:("Bristol-Myers Squibb Company") AND inv:"CORNELIUS, Lyndon, A., M." 第 1 页

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发明公开
MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80 (B7-1)/PD-LI PROTEIN/PROTEIN INTERACTIONS 审中-公开
标题翻译：大鼠PD-1 / PD-L1和CD80（B7-1）/ PD-LI蛋白/蛋白质相互作用的抑制剂

公开(公告)号：EP3191113A1

公开(公告)日：2017-07-19

申请号：EP14776949.1

申请日：2014-09-11

申请人： Bristol-Myers Squibb Company

发明人： MILLER, Michael Matthew , MAPELLI, Claudio , ALLEN, Martin Patrick , BOWSHER, Michael S. , GILLIS, Eric P. , LANGLEY, David R. , MULL, Eric , POIRIER, Maude A. , SANGHVI, Nishith , SUN, Li-Qiang , TENNEY, Daniel J. , YEUNG, Kap-Sun , ZHU, Juliang , GILLMAN, Kevin W. , ZHAO, Qian , GRANT-YOUNG, Katharine A. , SCOLA, Paul Michael , CORNELIUS, Lyndon, A., M.

IPC分类号： A61K38/10 , C07K7/08 , G01N33/574

CPC分类号： C07K7/64 , A61K38/00 , A61K38/12 , A61K45/06 , C07K7/08 , Y02A50/463

摘要： The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.

摘要翻译： 本公开提供了抑制PD-1 / PD-L1和PD-L1 / CD80蛋白质/蛋白质相互作用的新型大环肽，因此可用于改善各种疾病，包括癌症和感染性疾病。