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1.发明公开
公开(公告)号：EP2069328A2
公开(公告)日：2009-06-17
申请号：EP07813277.6
申请日：2007-07-24
IPC分类号： C07D401/12 , C07D401/14 , C07D413/14 , A61K31/4465 , A61K31/4545 , A61P25/00
CPC分类号： C07D401/12 , C07D401/14 , C07D413/14
摘要： The invention encompasses compounds of Formula I, including pharmaceutically acceptable salts, their pharmaceutical compositions, and their use in treating CNS disorders.
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公开(公告)号：EP2638022A1
公开(公告)日：2013-09-18
申请号：EP11785233.5
申请日：2011-11-04
发明人： DEGNAN, Andrew P. , HUANG, Hong , SNYDER, Lawrence B. , YANG, Fukang , GILLMAN, Kevin W. , PARKER, Michael F.
IPC分类号： C07D263/18 , C07D413/04 , C07D413/10 , C07D413/14
CPC分类号： C07D413/04 , C07D263/18 , C07D413/10 , C07D413/14
摘要： The disclosure generally relates to compounds of formula I, including their salts, as well as compositions and methods of using the compounds. The compounds are ligands, agonists and partial agonists for the mGluR5 receptor and may be useful for the treatment of various disorders of the central nervous system.
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公开(公告)号：EP3218392B1
公开(公告)日：2020-07-29
申请号：EP15801052.0
申请日：2015-11-12
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4.发明授权A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION 有权NEW ALPHA（N亚磺酰氨基）乙酰胺化合物作为抑制剂β淀粉样肽的生产
公开(公告)号：EP2205575B1
公开(公告)日：2011-03-16
申请号：EP08843687.8
申请日：2008-10-14
IPC分类号： C07D271/06 , A61K31/4245 , A61P25/28
CPC分类号： C07C311/19 , C07C237/06 , C07C253/30 , C07D271/06 , Y02P20/582 , C07C255/50
摘要： The present invention provides a novel alpha-(N-sulfonamido)acetamide compound, its pharmaceutical composition, processes thereof and a method for the treatment of Alzheimer's disease and other conditions associated with β- amyloid peptide.
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5.发明公开
公开(公告)号：EP2408757A1
公开(公告)日：2012-01-25
申请号：EP10723826.3
申请日：2010-03-18
IPC分类号： C07D271/06 , A61K31/4245 , A61P25/16
CPC分类号： C07D271/06 , A61K31/4245
摘要： The present disclosure provides novel deuterated alpha-(N-sulfonamido)acetamide compounds, their pharmaceutical composition, processes thereof and a method for the treatment of Alzheimer's disease, head trauma, traumatic brain injury, and/or dementia pugilistica and/or other conditions associated with &bgr;-amyloid peptide.
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6.发明公开A NOVEL ALPHA-(N-SULFONAMIDO)ACETAMIDE COMPOUND AS AN INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION 有权NEE ALPHA-（N-SULFONAMIDO）乙酰胺UNG UNG UNG UNG UNG OR OR D TION TION TION TION TION TION TION TION TION TION TION TION TION TION
公开(公告)号：EP2205575A1
公开(公告)日：2010-07-14
申请号：EP08843687.8
申请日：2008-10-14
IPC分类号： C07D271/06 , A61K31/4245 , A61P25/28
CPC分类号： C07C311/19 , C07C237/06 , C07C253/30 , C07D271/06 , Y02P20/582 , C07C255/50
摘要： The present invention provides a novel alpha-(N-sulfonamido)acetamide compound, its pharmaceutical composition, processes thereof and a method for the treatment of Alzheimer's disease and other conditions associated with β- amyloid peptide.
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公开(公告)号：EP3218392A1
公开(公告)日：2017-09-20
申请号：EP15801052.0
申请日：2015-11-12
发明人： GILLMAN, Kevin W. , GOODRICH, Jason , BOY, Kenneth M. , ZHANG, Yunhui , MAPELLI, Claudio , POSS, Michael A. , SUN, Li-Qiang , ZHAO, Qian , MULL, Eric , GILLIS, Eric P. , SCOLA, Paul Michael , LANGLEY, David, R. , MEANWELL, M. Nicholas
摘要： The present disclosure provides compounds which are immunomodulators and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
摘要翻译： 本公开提供了作为免疫调节剂的化合物，因此可用于改善各种疾病，包括癌症和感染性疾病。
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8.发明公开MACROCYCLIC INHIBITORS OF THE PD-1/PD-L1 AND CD80 (B7-1)/PD-LI PROTEIN/PROTEIN INTERACTIONS 审中-公开大鼠PD-1 / PD-L1和CD80（B7-1）/ PD-LI蛋白/蛋白质相互作用的抑制剂
公开(公告)号：EP3191113A1
公开(公告)日：2017-07-19
申请号：EP14776949.1
申请日：2014-09-11
发明人： MILLER, Michael Matthew , MAPELLI, Claudio , ALLEN, Martin Patrick , BOWSHER, Michael S. , GILLIS, Eric P. , LANGLEY, David R. , MULL, Eric , POIRIER, Maude A. , SANGHVI, Nishith , SUN, Li-Qiang , TENNEY, Daniel J. , YEUNG, Kap-Sun , ZHU, Juliang , GILLMAN, Kevin W. , ZHAO, Qian , GRANT-YOUNG, Katharine A. , SCOLA, Paul Michael , CORNELIUS, Lyndon, A., M.
IPC分类号： A61K38/10 , C07K7/08 , G01N33/574
摘要： The present disclosure provides novel macrocyclic peptides which inhibit the PD-1/PD-L1 and PD-L1/CD80 protein/protein interaction, and thus are useful for the amelioration of various diseases, including cancer and infectious diseases.
摘要翻译： 本公开提供了抑制PD-1 / PD-L1和PD-L1 / CD80蛋白质/蛋白质相互作用的新型大环肽，因此可用于改善各种疾病，包括癌症和感染性疾病。
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公开(公告)号：EP2638022B1
公开(公告)日：2014-12-24
申请号：EP11785233.5
申请日：2011-11-04
发明人： DEGNAN, Andrew P. , HUANG, Hong , SNYDER, Lawrence B. , YANG, Fukang , GILLMAN, Kevin W. , PARKER, Michael F.
IPC分类号： C07D263/18 , C07D413/04 , C07D413/10 , C07D413/14
CPC分类号： C07D413/04 , C07D263/18 , C07D413/10 , C07D413/14
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10.发明授权A NOVEL ALPHA-(N-SULFONAMIDO) ACETAMIDE COMPOUND INCORPORATING DEUTERIUM AS INHIBITOR OF BETA AMYLOID PEPTIDE PRODUCTION 有权NEW氘化ALPHA（N-磺酰氨基）乙酰胺作为抑制剂β淀粉样肽的生产
公开(公告)号：EP2408757B1
公开(公告)日：2014-06-25
申请号：EP10723826.3
申请日：2010-03-18
IPC分类号： C07D271/06 , A61K31/4245 , A61P25/16
CPC分类号： C07D271/06 , A61K31/4245
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