- 专利标题： INHIBITORS OF THE RENAL OUTER MEDULLARY POTASSIUM CHANNEL
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申请号： EP15854604申请日： 2015-10-26
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公开(公告)号： EP3212616A4公开(公告)日： 2018-05-16
- 发明人: PASTERNAK ALEXANDER , DONG SHUZHI , GU XIN , JIANG JINLONG , SHI ZHI-CAI , WALSH SHAWN P , WU ZHICAI , YU YANG , FERGUSON RONALD II , GUO ZHIQIANG , FRIE JESSICA , SUZUKI TAKAO , BLIZZARD TIMOTHY A , FU QINGHONG , VANGELDER KELSEY F
- 申请人： MERCK SHARP & DOHME
- 专利权人： MERCK SHARP & DOHME
- 当前专利权人： MERCK SHARP & DOHME
- 优先权： CN2014089930 2014-10-30
- 主分类号： C07D471/10
- IPC分类号： C07D471/10 ; A61P3/14 ; A61P7/10 ; A61P9/12 ; C07D497/10
摘要：
The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.
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