公开(公告)号：EP3212616A4

公开(公告)日：2018-05-16

申请号：EP15854604

申请日：2015-10-26

申请人： MERCK SHARP & DOHME

发明人： PASTERNAK ALEXANDER ,  DONG SHUZHI ,  GU XIN ,  JIANG JINLONG ,  SHI ZHI-CAI ,  WALSH SHAWN P ,  WU ZHICAI ,  YU YANG ,  FERGUSON RONALD II ,  GUO ZHIQIANG ,  FRIE JESSICA ,  SUZUKI TAKAO ,  BLIZZARD TIMOTHY A ,  FU QINGHONG ,  VANGELDER KELSEY F

IPC分类号： C07D471/10 ,  A61P3/14 ,  A61P7/10 ,  A61P9/12 ,  C07D497/10

CPC分类号： C07D498/10 ,  A61K31/401 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/4422 ,  A61K31/444 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/551 ,  A61K31/585 ,  A61K31/675 ,  A61P3/14 ,  A61P7/10 ,  A61P9/12 ,  C07D471/10 ,  C07D497/10 ,  A61K2300/00

摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

公开(公告)号：EP3027625A4

公开(公告)日：2017-03-15

申请号：EP14831878

申请日：2014-07-28

申请人： MERCK SHARP & DOHME

发明人： TANG HAIFENG ,  PIO BARBARA ,  JIANG JINLONG ,  PASTERNAK ALEXANDER ,  DONG SHUZHI ,  FERGUSON RONALD DALE II ,  GUO ZACK ZHIQIANG ,  CHOBANIAN HARRY ,  FRIE JESSICA ,  GUO YAN ,  WU ZHICAI ,  YU YANG ,  WANG MING

IPC分类号： C07D498/12

CPC分类号： C07D471/10 ,  A61K31/435 ,  A61K31/444 ,  A61K31/46 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/5386 ,  A61K45/06 ,  C07D451/00 ,  C07D493/04 ,  C07D498/10

摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.

摘要翻译： 本发明提供式I化合物及其药学上可接受的盐，它们是ROMK（Kir1.1）通道的抑制剂。 这些化合物可以用作利尿剂和/或利尿钠剂，并且用于治疗和预防包括心血管疾病如高血压，心力衰竭和慢性肾脏疾病以及与过量的盐和水保留有关的病症的医学病症。