公开(公告)号：EP3212616A4

公开(公告)日：2018-05-16

申请号：EP15854604

申请日：2015-10-26

申请人： MERCK SHARP & DOHME

发明人： PASTERNAK ALEXANDER ,  DONG SHUZHI ,  GU XIN ,  JIANG JINLONG ,  SHI ZHI-CAI ,  WALSH SHAWN P ,  WU ZHICAI ,  YU YANG ,  FERGUSON RONALD II ,  GUO ZHIQIANG ,  FRIE JESSICA ,  SUZUKI TAKAO ,  BLIZZARD TIMOTHY A ,  FU QINGHONG ,  VANGELDER KELSEY F

IPC分类号： C07D471/10 ,  A61P3/14 ,  A61P7/10 ,  A61P9/12 ,  C07D497/10

CPC分类号： C07D498/10 ,  A61K31/401 ,  A61K31/41 ,  A61K31/4178 ,  A61K31/4184 ,  A61K31/435 ,  A61K31/4422 ,  A61K31/444 ,  A61K31/4965 ,  A61K31/497 ,  A61K31/501 ,  A61K31/506 ,  A61K31/519 ,  A61K31/5386 ,  A61K31/55 ,  A61K31/551 ,  A61K31/585 ,  A61K31/675 ,  A61P3/14 ,  A61P7/10 ,  A61P9/12 ,  C07D471/10 ,  C07D497/10 ,  A61K2300/00

摘要： The present invention provides compounds of Formula I and the pharmaceutically acceptable salts thereof, which are inhibitors of the ROMK (Kir1.1) channel. The compounds may be used as diuretic and/or natriuretic agents and for the therapy and prophylaxis of medical conditions including cardiovascular diseases such as hypertension, heart failure and chronic kidney disease and conditions associated with excessive salt and water retention.