- 专利标题： NEUTRALIZING ANTIBODIES TO HIV-1 GP41 AND THEIR USE
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申请号： EP16801639.2申请日： 2016-11-03
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公开(公告)号： EP3371214A1公开(公告)日： 2018-09-12
- 发明人: KWONG, Peter , KWON, Young, Do , GEORGIEV, Ivelin , OFEK, Gilad , ZHANG, Baoshan , MCKEE, Krisha , MACSOLA, John , CHUANG, Gwo-Yu , O'DELL, Sijy , GINDIN, Tatyana , SHAPIRO, Lawrence , BAILER, Robert , LOUDER, Mark , ASOKAN, Mangaiarkarasi , SCHWARTZ, Richard , COOPER, Jonathan , CARLTON, Kevin , BENDER, Michael , CONNORS, Mark , PEGU, Amarendra , KUELTZO, Lisa
- 申请人： THE UNITED STATES OF AMERICA, represented by the S , The Trustees of Columbia University in the City of New York
- 申请人地址： ECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; National Institutes of Health; Office of Technology Transfer; 6011 Executive Boulevard, Suite 325; MSC 7660; Bethesda, MD 20852-7660 US
- 专利权人： THE UNITED STATES OF AMERICA, represented by the S,The Trustees of Columbia University in the City of New York
- 当前专利权人： THE UNITED STATES OF AMERICA, represented by the S,The Trustees of Columbia University in the City of New York
- 当前专利权人地址： ECRETARY, DEPARTMENT OF HEALTH AND HUMAN SERVICES; National Institutes of Health; Office of Technology Transfer; 6011 Executive Boulevard, Suite 325; MSC 7660; Bethesda, MD 20852-7660 US
- 代理机构： Gowshall, Jonathan Vallance
- 优先权： US201562250360P 20151103
- 国际公布： WO2017079479 20170511
- 主分类号： C07K16/10
- IPC分类号： C07K16/10
摘要：
Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.
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