公开(公告)号：EP3371214A1

公开(公告)日：2018-09-12

申请号：EP16801639.2

申请日：2016-11-03

申请人： THE UNITED STATES OF AMERICA, represented by the S ,  The Trustees of Columbia University in the City of New York

发明人： KWONG, Peter ,  KWON, Young, Do ,  GEORGIEV, Ivelin ,  OFEK, Gilad ,  ZHANG, Baoshan ,  MCKEE, Krisha ,  MACSOLA, John ,  CHUANG, Gwo-Yu ,  O'DELL, Sijy ,  GINDIN, Tatyana ,  SHAPIRO, Lawrence ,  BAILER, Robert ,  LOUDER, Mark ,  ASOKAN, Mangaiarkarasi ,  SCHWARTZ, Richard ,  COOPER, Jonathan ,  CARLTON, Kevin ,  BENDER, Michael ,  CONNORS, Mark ,  PEGU, Amarendra ,  KUELTZO, Lisa

IPC分类号： C07K16/10

CPC分类号： C07K16/1063 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

公开(公告)号：EP4011911A1

公开(公告)日：2022-06-15

申请号：EP21204045.5

申请日：2016-11-03

申请人： The United States of America as represented by The Secretary Department of Health and Human Services ,  The Trustees of Columbia University in the City of New York

发明人： KWONG, Peter ,  KWON, Young Do ,  GEORGIEV, Ivelin ,  OFEK, Gilad ,  ZHANG, Baoshan ,  MCKEE, Krisha ,  MACSOLA, John ,  CHUANG, Gwo-Yu ,  O'DELL, Sijy ,  GINDIN, Tatyana ,  SHAPIRO, Lawrence ,  BAILER, Robert ,  LOUDER, Mark ,  ASOKAN, Mangaiarkarasi ,  SCHWARTZ, Richard ,  COOPER, Jonathan ,  CARLTON, Kevin ,  BENDER, Michael ,  CONNORS, Mark ,  PEGU, Amarendra ,  KUELTZO, Lisa

IPC分类号： C07K16/10

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

公开(公告)号：EP2788376A1

公开(公告)日：2014-10-15

申请号：EP12855597.6

申请日：2012-12-10

申请人： THE UNITED STATES OF AMERICA, represented by the S

发明人： KWONG, Peter, D. ,  NABEL, Gary, J. ,  RUDICELL, Rebecca, S. ,  MASCOLA, John ,  CONNORS, Mark ,  GEORGIEV, Ivelin ,  ZHU, Jiang ,  KWON, Young, Do ,  ZHOU, Tongqing ,  YANG, Yongping ,  ZHANG, Baoshan ,  CHUANG, Gwo-yu ,  WU, Xueling ,  YANG, Zhi-yong ,  SHI, Wei

IPC分类号： C07K16/10 ,  A61K39/42 ,  A61P31/18 ,  C12N15/13 ,  G01N33/569

CPC分类号： C07K16/1063 ,  A61K39/42 ,  A61K45/06 ,  A61K2039/505 ,  C07K2317/21 ,  C07K2317/41 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/72 ,  C07K2317/76 ,  C07K2317/92 ,  G01N33/56983 ,  G01N33/56988

摘要： Monoclonal neutralizing antibodies that specifically bind to HIV-1 gp120 and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV infection is disclosed.