公开(公告)号：EP3371214A1

公开(公告)日：2018-09-12

申请号：EP16801639.2

申请日：2016-11-03

申请人： THE UNITED STATES OF AMERICA, represented by the S ,  The Trustees of Columbia University in the City of New York

发明人： KWONG, Peter ,  KWON, Young, Do ,  GEORGIEV, Ivelin ,  OFEK, Gilad ,  ZHANG, Baoshan ,  MCKEE, Krisha ,  MACSOLA, John ,  CHUANG, Gwo-Yu ,  O'DELL, Sijy ,  GINDIN, Tatyana ,  SHAPIRO, Lawrence ,  BAILER, Robert ,  LOUDER, Mark ,  ASOKAN, Mangaiarkarasi ,  SCHWARTZ, Richard ,  COOPER, Jonathan ,  CARLTON, Kevin ,  BENDER, Michael ,  CONNORS, Mark ,  PEGU, Amarendra ,  KUELTZO, Lisa

IPC分类号： C07K16/10

CPC分类号： C07K16/1063 ,  C07K2317/21 ,  C07K2317/33 ,  C07K2317/52 ,  C07K2317/565 ,  C07K2317/567 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.

公开(公告)号：EP4011911A1

公开(公告)日：2022-06-15

申请号：EP21204045.5

申请日：2016-11-03

申请人： The United States of America as represented by The Secretary Department of Health and Human Services ,  The Trustees of Columbia University in the City of New York

发明人： KWONG, Peter ,  KWON, Young Do ,  GEORGIEV, Ivelin ,  OFEK, Gilad ,  ZHANG, Baoshan ,  MCKEE, Krisha ,  MACSOLA, John ,  CHUANG, Gwo-Yu ,  O'DELL, Sijy ,  GINDIN, Tatyana ,  SHAPIRO, Lawrence ,  BAILER, Robert ,  LOUDER, Mark ,  ASOKAN, Mangaiarkarasi ,  SCHWARTZ, Richard ,  COOPER, Jonathan ,  CARLTON, Kevin ,  BENDER, Michael ,  CONNORS, Mark ,  PEGU, Amarendra ,  KUELTZO, Lisa

IPC分类号： C07K16/10

摘要： Neutralizing antibodies that specifically bind to HIV-1 Env and antigen binding fragments of these antibodies are disclosed. Nucleic acids encoding these antibodies, vectors and host cells are also provided. Methods for detecting HIV-1 using these antibodies are disclosed. In addition, the use of these antibodies, antigen binding fragment, nucleic acids and vectors to prevent and/or treat an HIV-1 infection is disclosed.