- 专利标题： FUSED PYRIMIDINES AS ISOFORM SELECTIVE PHOSPHOINOSITIDE-3-KINASE-ALPHA INHIBITORS AND PROCESS FOR PREPARATION THEREOF
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申请号： EP16834199.8申请日： 2016-11-21
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公开(公告)号： EP3380476A1公开(公告)日： 2018-10-03
- 发明人: BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MOHAMMED, Shabber , GURU, Santosh Kumar , BHARATE, Sonali Sandip , KUMAR, Vikas , MAHAJAN, Girish , MINTOO, Mubashir Javed , MONDHE, Dilip Manikrao , VISHWAKARMA, Ram
- 申请人： Council of Scientific and Industrial Research
- 申请人地址： Anusandhan Bhawan Rafi Marg New Delhi 110001 IN
- 专利权人： Council of Scientific and Industrial Research
- 当前专利权人： Council of Scientific and Industrial Research
- 当前专利权人地址： Anusandhan Bhawan Rafi Marg New Delhi 110001 IN
- 代理机构： AWA Sweden AB
- 优先权： IN3818DE2015 20151123
- 国际公布： WO2017090058 20170601
- 主分类号： C07D491/147
- IPC分类号： C07D491/147 ; C07D495/04 ; A61K31/519 ; A61K31/5377 ; A61P35/00
摘要：
The present invention relates to fused pyrimidines of formulae I and II wherein, R1, R2 are as herein described. The present invention particularly relates to isoform selective PI3Kα inhibition and their medicinal use as anticancer agents.
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