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公开(公告)号：EP3212235B1
公开(公告)日：2018-11-28
申请号：EP15807704.0
申请日：2015-10-21
发明人： VISHWAKARMA, Ram , KUMAR, Ajay , KHAN, Inshad Ali , BHARATE, Sandip Bibishan , JOSHI, Prashant , SINGH, Samsher , SATTI, Naresh
IPC分类号： A61K45/06 , A61K31/351 , A61K31/352 , A61K31/496 , A61K31/7048 , A61P31/04
CPC分类号： A61K31/352 , A61K31/351 , A61K31/496 , A61K31/7048 , A61K36/185 , A61K45/06 , Y02A50/401 , Y02A50/47 , Y02A50/471 , Y02A50/473 , Y02A50/475 , Y02A50/478 , Y02A50/483 , A61K2300/00
摘要： The bio-efficacy of anti-infective drugs can be potentiated, when used in combination with boeravinone B. Boeravinone B can overcome the resistance or multi-drug resistance developed by bacteria against quinolone, mupirocin and macrolide class of anti-bacterial agents via inhibition of bacterial efflux pumps. Thus, the compositions can be used to treat or prevent drug-resistant bacterial diseases.
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2.发明公开
公开(公告)号：EP3380476A1
公开(公告)日：2018-10-03
申请号：EP16834199.8
申请日：2016-11-21
发明人： BHARATE, Sandip Bibishan , BHUSHAN, Shashi , MOHAMMED, Shabber , GURU, Santosh Kumar , BHARATE, Sonali Sandip , KUMAR, Vikas , MAHAJAN, Girish , MINTOO, Mubashir Javed , MONDHE, Dilip Manikrao , VISHWAKARMA, Ram
IPC分类号： C07D491/147 , C07D495/04 , A61K31/519 , A61K31/5377 , A61P35/00
摘要： The present invention relates to fused pyrimidines of formulae I and II wherein, R1, R2 are as herein described. The present invention particularly relates to isoform selective PI3Kα inhibition and their medicinal use as anticancer agents.
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公开(公告)号：EP3781133A1
公开(公告)日：2021-02-24
申请号：EP19723887.6
申请日：2019-04-18
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公开(公告)号：EP3207026B1
公开(公告)日：2018-12-12
申请号：EP15805323.1
申请日：2015-10-14
发明人： VISHWAKARMA, Ram , BHARATE, Sandip Bibishan , KUMAR, Ajay , SINGH, Baljinder , KUMAR, Ashok , BHUSHAN, Shashi , HAMID, Abid , JOSHI, Prashant , GURU, Santosh Kumar , KUMAR, Suresh , HUSSAIN, Aashiq , QAZI, Asif Khurshid , BHARATE, Sonali Sandip , SHARMA, Parduman , SAXENA, Ajit Kumar , MONDHE, Dilip Manikrao , MAHAJAN, Girish , WANI, Zahoor
IPC分类号： C07C233/41
CPC分类号： C07C233/41 , A61K31/165 , C07C231/12 , C07C2603/34
摘要： The present invention relates to the compounds of formula I wherein R is as herein described. The present invention particularly relates to synthesis and antiproliferative activity of 10-substituted colchicinoids. Compounds of the invention can be used for prevention or in the treatment of cancer disease.
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5.发明公开N-SUBSTITUTED BETA-CARBOLINIUM COMPOUNDS AS POTENT P-GLYCOPROTEIN INDUCERS 审中-公开N-取代的β-咔啉化合物作为有效的β-糖蛋白诱导剂
公开(公告)号：EP3227291A1
公开(公告)日：2017-10-11
申请号：EP15807703.2
申请日：2015-10-21
发明人： BHARATE, Sandip , KUMAR, Ajay , MANDA, Sudhakar , JOSHI, Prashant , BHARATE, Sonali , VISHWAKARMA, Ram
IPC分类号： C07D471/04 , C07D471/14 , A61K31/437 , A61P25/28
CPC分类号： C07D471/14 , C07D471/04
摘要： The present invention relates to the N-substituted beta-carbolinium compounds of general formula A and formulae I and II wherein, R1 and R2 groups are selected from halogens or trifluoromethyl; R3 group is selected from hydrogen or methyl; Ar is selected from aryl and heteroaryl, X is selected from halogens; and R1 and R2 groups may be attached to any position on ring E. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the N-substituted beta-carbolinium compounds. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.
摘要翻译： 本发明涉及通式A和式I和II的N-取代的β-咔啉鎓化合物，其中R 1和R 2基团选自卤素或三氟甲基; R 3基团选自氢或甲基; Ar选自芳基和杂芳基，X选自卤素; 并且R 1和R 2基团可以连接到环E上的任何位置。本发明特别涉及N-取代的β-咔啉鎓化合物的合成和β-糖蛋白诱导活性。 另外，本发明涉及使用化合物治疗或预防阿尔茨海默氏病的方法。
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公开(公告)号：EP3227291B1
公开(公告)日：2019-05-15
申请号：EP15807703.2
申请日：2015-10-21
发明人： BHARATE, Sandip , KUMAR, Ajay , MANDA, Sudhakar , JOSHI, Prashant , BHARATE, Sonali , VISHWAKARMA, Ram
IPC分类号： C07D471/04 , C07D471/14 , A61K31/437 , A61P25/28
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公开(公告)号：EP3209671A1
公开(公告)日：2017-08-30
申请号：EP15787031.2
申请日：2015-09-16
发明人： BHARATE, Sandip , KUMAR, Ajay , MANDA, Sudhakar , JOSHI, Prashant , BHARATE, Sonali , WANI, Abubakar , SHARMA, Sadhana , VISHWAKARMA, Ram
IPC分类号： C07F9/655 , C07F9/40 , A61K31/665 , A61K31/663 , A61P25/28
CPC分类号： C07F9/65515 , C07F9/4031 , C07F9/4034 , C07F9/4037 , C07F9/404 , C07F9/405
摘要： The present invention relates to the alkylidene phosphonate esters of formula I wherein, R1 is selected from a group consisting of hydrogen or alkyl group; R2 is selected from a group consisting of hydrogen, hydroxy, alkyl, alkoxy, nitro, halogen, amino, N- substituted alkylamino; alkyl group is selected from a group consisting of methyl, ethyl and isopropyl; Ar is selected from a group consisting of aryl, substituted aryl, fused aryl, heteroaryl, and substituted heteroaryl. The present invention particularly relates to synthesis and p-glycoprotein induction activity of the alkylidene phosphonate esters. In addition, the invention relates to methods of using compounds for treating or preventing Alzheimer's disease.
摘要翻译： 本发明涉及式I的亚烷基膦酸酯，其中R 1选自氢或烷基; R2选自氢，羟基，烷基，烷氧基，硝基，卤素，氨基，N-取代的烷基氨基; 烷基选自甲基，乙基和异丙基; Ar选自由芳基，取代的芳基，稠合的芳基，杂芳基和取代的杂芳基组成的组。 本发明特别涉及亚烷基膦酸酯的合成和p-糖蛋白诱导活性。 另外，本发明涉及使用化合物治疗或预防阿尔茨海默氏病的方法。
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8.发明公开POLYPRENYLATED PHLOROGLUCINOL COMPOUNDS AS POTENT P-GLYCOPROTEIN INDUCERS 审中-公开聚丙烯酸羟基亮黄酮化合物作为P-glycoprotin诱导剂
公开(公告)号：EP3209638A1
公开(公告)日：2017-08-30
申请号：EP15774722.1
申请日：2015-07-20
发明人： BHARATE, Sandip , KUMAR, Ajay , BHARATE, Jaideep , JOSHI, Prashant , WANI, Abubakar , MUDUDUDDLA, Ramesh , SHARMA, Rohit , VISHWAKARMA, Ram
IPC分类号： C07C205/34 , C07C49/733 , C07C53/122 , C07C59/90 , A61K31/122 , A61P25/28 , C07D311/96
摘要： The present invention relates to the polyprenylated phloroglucinol compounds of formulae I and II. The present invention also provides synthesis and p-glycoprotein induction activity of the alkyl- and acyl-polyprenylated phloroglucinol compounds. Further, use of the compounds as p-glycoprotein inducers and methods of treatment of Alzheimer's disease using compounds of the invention are also provided.
摘要翻译： 本发明涉及式I和II的聚丙烯化间苯三酚化合物。 本发明还提供烷基和酰基聚丙烯化间苯三酚化合物的合成和p-糖蛋白诱导活性。 此外，还提供了使用这些化合物作为P-糖蛋白诱导剂和使用本发明化合物治疗阿尔茨海默病的方法。
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公开(公告)号：EP2010202B1
公开(公告)日：2013-09-25
申请号：EP07735435.5
申请日：2007-04-10
发明人： MAHAJAN, Girish, Badrinath , GEORGE, Saji, David , RANADIVE, Prafull, Vasant , MISHRA, Prabhu Dutt, Satyanarayan , EYYAMMADICHIYIL, Sreekumar, Sankaranarayanan , PANSHIKAR, Rajan, Mukund , SAWANT, Satish, Namdeo , KRISHNA, Sridevi , SIVAKUMAR, Meenakshi , PARI, Koteppa , THOMAS, Becky, Mary , PATEL, Zarine, Eruch , VISHWAKARMA, Ram , NAIK, Chandrakant, Govind , D'SOUZA, Lisette , DEVI, Prabha
CPC分类号： A61K38/12 , C07K5/0821
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公开(公告)号：EP2010202A2
公开(公告)日：2009-01-07
申请号：EP07735435.5
申请日：2007-04-10
发明人： MAHAJAN, Girish, Badrinath , GEORGE, Saji, David , RANADIVE, Prafull, Vasant , MISHRA, Prabhu Dutt, Satyanarayan , EYYAMMADICHIYIL, Sreekumar, Sankaranarayanan , PANSHIKAR, Rajan, Mukund , SAWANT, Satish, Namdeo , KRISHNA, Sridevi , SIVAKUMAR, Meenakshi , PARI, Koteppa , THOMAS, Becky, Mary , PATEL, Zarine, Eruch , VISHWAKARMA, Ram , NAIK, Chandrakant, Govind , D'SOUZA, Lisette , DEVI, Prabha
IPC分类号： A61K38/12
CPC分类号： A61K38/12 , C07K5/0821
摘要： This invention relates to a novel purified compound PM181104, of formula (I) of molecular weight 1514 and molecular formula C69H66N18O13S5; which is obtained by fermentation of the microorganism belonging to Kocuria species (ZMA B-1 / MTCC 5269). The invention includes all stereoisomeric forms and all tautomeric forms of the compound PM181104 and pharmaceutically acceptable salts and derivatives such as esters and ethers. The present invention further relates to processes for the production of the novel antibacterial compound(s), to the production of the microorganism belonging to Kocuria species (ZMA B-1 / MTCC 5269), and to pharmaceutical compositions containing the novel compound(s) as an active ingredient and its/their use in medicines for treatment and prevention of diseases caused by bacterial infections.
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