- 专利标题： ANTIBODIES AGAINST CD73 AND USES THEREOF
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申请号： EP20164125.5申请日： 2015-11-19
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公开(公告)号： EP3725808A1公开(公告)日： 2020-10-21
- 发明人: LONBERG, Nils , KORMAN, Alan J. , BARNHART, Bryan C. , YAMNIUK, Aaron P. , SRINIVASAN, Mohan , HENNING, Karla A. , LEI, Ming , SEGA, Emanuela , GOODENOUGH, Angela , JURE-KUNKEL, Maria N. , CHEN, Guodong , SACK, John , HUANG, Richard , CORBETT, Martin J. , MYERS, Joseph E. , SCHWEIZER, Liang , HATCHER, Sandra V. , HUANG, Haichun , ZHANG, Pingping
- 申请人： Bristol-Myers Squibb Company
- 申请人地址： Route 206 and Province Line Road Princeton, NJ 08543 US
- 专利权人： Bristol-Myers Squibb Company
- 当前专利权人： Bristol-Myers Squibb Company
- 当前专利权人地址： Route 206 and Province Line Road Princeton, NJ 08543 US
- 代理机构： Mewburn Ellis LLP
- 优先权： US201462083056P 20141121
- 主分类号： C07K16/28
- IPC分类号： C07K16/28 ; C07K16/40 ; C07K16/30 ; A61K39/395 ; A61P35/00
摘要：
The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.
公开/授权文献
- EP3725808B1 ANTIBODIES AGAINST CD73 AND USES THEREOF 公开/授权日：2024-07-17
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