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公开(公告)号：EP4098662A1
公开(公告)日：2022-12-07
申请号：EP22167890.7
申请日：2018-05-24
发明人： YAMNIUK, Aaron, P. , KORMAN, Alan, J. , SELBY, Mark, J. , BARNHART, Bryan, C. , LONBERG, Nils , SRINIVASAN, Mohan , HENNING, Karla, A. , HAN, Michelle, Minhua , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra, V , RAJPAL, Arvind
IPC分类号： C07K16/28
摘要： Provided herein are heavy chain constant regions (referred to as "modified heavy chain constant regions"), or functionally equivalent fragments thereof, that enhance biological properties of antibodies relative to the same antibodies in unmodified form. An exemplary modified heavy chain constant region includes an IgG2 hinge and three constant domains ( i.e., CHI, CH2, and CH3 domains), wherein one or more of the constant region domains are of a non-IgG2 isotype (e.g., IgG1, IgG3 or IgG4). The heavy chain constant region may comprise wildtype human IgG domain sequences, or variants of these sequences. Also provided herein are methods for enhancing certain biological properties of antibodies that comprise a non-IgG2 hinge, such as internalization, agonism and antagonism, wherein the method comprises replacing the non-IgG2 hinge of the antibody with an IgG2 hinge.
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公开(公告)号：EP3789399A1
公开(公告)日：2021-03-10
申请号：EP20187161.3
申请日：2015-11-19
发明人： LONBERG, Nils , KORMAN, Alan J. , SELBY, Mark J. , BARNHART, Bryan C. , YAMNIUK, Aaron P. , SRINIVASAN, Mohan , HENNING, Karla A. , HAN, Michelle Minhua , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra V. , RAJPAL, Arvind
摘要： Provided herein are heavy chain constant regions (referred to as "modified heavy chain constant regions"), or functionally equivalent fragments thereof, that enhance biological properties of antibodies relative to the same antibodies in unmodified form. An exemplary modified heavy chain constant region includes an IgG2 hinge and three constant domains ( i.e., CH1, CH2, and CH3 domains), wherein one or more of the constant region domains are of non-IgG2 isotype (e.g., IgG1, IgG3 or IgG4). The heavy chain constant region may comprise wildtype human IgG domain sequences, or variants of these sequences. Also provided herein are methods for enhancing certain biological properties of antibodies that comprise a non-IgG2 hinge, such as internalization, agonism and antagonism, wherein the method comprises replacing the non-IgG2 hinge of the antibody with an IgG2 hinge.
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公开(公告)号：EP3303396A1
公开(公告)日：2018-04-11
申请号：EP16729129.3
申请日：2016-05-26
发明人： CAI, Zhehong , CHAKRABORTY, Indrani , GARCIA, Marie-Michelle, Navarro , KEMPE, Thomas, D. , KORMAN, Alan, J. , KOZHICH, Alexander, T. , LEMAR, Hadia , MAURER, Mark , MILBURN, Christina, Maria , QUIGLEY, Michael , RODRIGUEZ, Maria , SHAO, Xiang , SRINIVASAN, Mohan , STEVENS, Brenda, L. , THUDIUM, Kent , WONG, Susan, Chien-Szu , GOKEMEIJER, Jochem , WANG, Xi-Tao , CHANG, Han , HUANG, Christine , JURE-KUNKEL, Maria , YANG, Zheng , FENG, Yan , GUIRNALDA, Patrick , LONBERG, Nils , BARNHART, Bryan C. , YAMNIUK, Aaron P. , HENNING, Karla A. , HAN, Michelle Minhua , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra V. , RAJPAL, Arvind , AANUR, Praveen , SELBY, Mark J.
IPC分类号： C07K16/28 , A61K39/395 , A61P35/00
CPC分类号： C07K16/2878 , A61K39/3955 , A61K2039/505 , A61K2039/507 , A61P35/00 , C07K16/2818 , C07K16/30 , C07K16/3023 , C07K16/3038 , C07K16/3069 , C07K2317/21 , C07K2317/24 , C07K2317/31 , C07K2317/33 , C07K2317/34 , C07K2317/52 , C07K2317/56 , C07K2317/565 , C07K2317/567 , C07K2317/73 , C07K2317/74 , C07K2317/75 , C07K2317/76 , C07K2317/92 , C07K2317/94 , G01N33/574
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to OX40. Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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公开(公告)号：EP3725808A1
公开(公告)日：2020-10-21
申请号：EP20164125.5
申请日：2015-11-19
发明人： LONBERG, Nils , KORMAN, Alan J. , BARNHART, Bryan C. , YAMNIUK, Aaron P. , SRINIVASAN, Mohan , HENNING, Karla A. , LEI, Ming , SEGA, Emanuela , GOODENOUGH, Angela , JURE-KUNKEL, Maria N. , CHEN, Guodong , SACK, John , HUANG, Richard , CORBETT, Martin J. , MYERS, Joseph E. , SCHWEIZER, Liang , HATCHER, Sandra V. , HUANG, Haichun , ZHANG, Pingping
IPC分类号： C07K16/28 , C07K16/40 , C07K16/30 , A61K39/395 , A61P35/00
摘要： The present invention provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the invention, expression vectors, host cells and methods for expressing the antibodies of the invention are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the invention are also provided. The invention also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the invention, including methods for treating various cancers.
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公开(公告)号：EP3221346B1
公开(公告)日：2020-09-02
申请号：EP15804282.0
申请日：2015-11-19
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公开(公告)号：EP3423494A1
公开(公告)日：2019-01-09
申请号：EP17712299.1
申请日：2017-03-03
发明人： BARNHART, Bryan, C. , KORMAN, Alan, J. , LONBERG, Nils , YAMNIUK, Aaron, P. , SRIVISAN, Mohan , HENNING, Karla, A. , LEI, Ming , SEGA, Emanuela , GOODENOUGH, Angela , JURE-KUNKEL, Maria , CHEN, Guodong , SACK, John, S. , HUANG, Richard, Y. , CORBETT, Martin, J. , MYERS, Joseph, E. Jr. , SCHWEIZER, Liang , HATCHER, Sandra, V. , ALTURA, Rachel , HUANG, Haichun , ZHANG, Pingping , HILT, Edward, J. , HEDRICK, Michael, Nathan
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公开(公告)号：EP3221363A2
公开(公告)日：2017-09-27
申请号：EP15816276.8
申请日：2015-11-19
发明人： LONBERG, Nils , KORMAN, Alan J. , BARNHART, Bryan C. , YAMNIUK, Aaron P. , SRINIVASAN, Mohan , HENNING, Karla A. , LEI, Ming , SEGA, Emanuela , GOODENOUGH, Angela , JURE-KUNKEL, Maria N. , CHEN, Guodong , SACK, John , HUANG, Richard , CORBETT, Martin J. , MYERS, Joseph E. , SCHWEIZER, Liang , HATCHER, Sandra V. , HUANG, Haichun , ZHANG, Pingping
IPC分类号： C07K16/28 , C07K16/40 , C07K16/30 , A61K39/395 , A61P35/00
摘要： The present disclosure provides isolated monoclonal antibodies, particularly human antibodies, that bind to human Cluster of Differentiation 73 (CD73) with high affinity, and inhibit the activity of CD73, and optionally mediate antibody dependent CD73 internalization. Nucleic acid molecules encoding the antibodies of the disclosure, expression vectors, host cells and methods for expressing the antibodies of the disclosure are also provided. Immunoconjugates, bispecific molecules and pharmaceutical compositions comprising the antibodies of the disclosure are also provided. The disclosure also provides methods for inhibiting the growth of a tumor cell expressing CD73 using the antibodies of the disclosure, including methods for treating various cancers.
摘要翻译： 本发明提供以高亲和力结合人分化簇73（CD73）并且抑制CD73的活性并且任选地介导抗体依赖性CD73内化的分离的单克隆抗体，特别是人抗体。 还提供了编码本发明抗体的核酸分子，表达载体，宿主细胞和表达本发明抗体的方法。 还提供了包含本发明抗体的免疫缀合物，双特异性分子和药物组合物。 本发明还提供了使用本发明的抗体抑制表达CD73的肿瘤细胞生长的方法，包括治疗各种癌症的方法。
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公开(公告)号：EP3221346A2
公开(公告)日：2017-09-27
申请号：EP15804282.0
申请日：2015-11-19
发明人： LONBERG, Nils , KORMAN, Alan J. , SELBY, Mark J. , BARNHART, Bryan C. , YAMNIUK, Aaron P. , SRINIVASAN, Mohan , HENNING, Karla A. , HAN, Michelle Minhua , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra V. , RAJPAL, Arvind
摘要： Provided herein are heavy chain constant regions (referred to as “modified heavy chain constant regions”), or functionally equivalent fragments thereof, that enhance biological properties of antibodies relative to the same antibodies in unmodified form. An exemplary modified heavy chain constant region includes an IgG2 hinge and three constant domains (i.e., CH1, CH2, and CH3 domains), wherein one or more of the constant region domains are of a non-IgG2 isotype (e.g., IgG1, IgG3 or IgG4). The heavy chain constant region may comprise wildtype human IgG domain sequences, or variants of these sequences. Also provided herein are methods for enhancing certain biological properties of antibodies that comprise a non-IgG2 hinge, such as internalization, agonism and antagonism, wherein the method comprises replacing the non-IgG2 hinge of the antibody with an IgG2 hinge.
摘要翻译： 本文提供了增强抗体相对于未修饰形式的相同抗体的生物学特性的重链恒定区（称为“修饰的重链恒定区”）或其功能等同片段。 示例性的修饰的重链恒定区包括IgG2铰链和三个恒定结构域（即，CH1，CH2和CH3结构域），其中一个或多个恒定区结构域具有非IgG2同种型（例如IgG1，IgG3或 IgG4的）。 重链恒定区可以包含野生型人IgG结构域序列或这些序列的变体。 本文还提供了用于增强包含非-IgG2铰链的抗体的某些生物学特性（例如内化，激动和拮抗）的方法，其中所述方法包括用IgG2铰链代替抗体的非IgG2铰链。
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公开(公告)号：EP3630833A1
公开(公告)日：2020-04-08
申请号：EP18731658.3
申请日：2018-05-24
发明人： YAMNIUK, Aaron, P. , KORMAN, Alan, J. , SELBY, Mark, J. , BARNHART, Bryan, C. , LONBERG, Nils , SRINIVASAN, Mohan , HENNING, Karla, A. , HAN, Michelle, Minhua , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra, V. , RAJPAL, Arvind
IPC分类号： C07K16/28
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10.发明公开
公开(公告)号：EP3377532A2
公开(公告)日：2018-09-26
申请号：EP16805668.7
申请日：2016-11-17
发明人： WANG, Changyu , LONBERG, Nils , KORMAN, Alan, J. , SELBY, Mark, J. , SRINIVASAN, Mohan , HENNING, Karla, A. , HAN, Michelle, Minhua , CHEN, Guodong , HUANG, Richard , CHAKRABORTY, Indrani , HUANG, Haichun , WONG, Susan, Chien-Szu , LI, Huiming , BARNHART, Bryan, C. , YAMNIUK, Aaron, P. , LEI, Ming , SCHWEIZER, Liang , HATCHER, Sandra, V. , RAJPAL, Arvind
CPC分类号： A61K39/39558 , A61K2039/507 , A61K2039/572 , A61P35/04 , C07K16/2818 , C07K16/2878 , C07K2317/21 , C07K2317/34 , C07K2317/732 , C07K2317/75 , C07K2317/77 , C07K2317/92 , G01N33/574 , G01N33/6863
摘要： Provided herein are antibodies, or antigen binding portions thereof, that bind to glucocorticoid-inducible TNF receptor (GITR). Also provided are uses of these proteins in therapeutic applications, such as in the treatment of cancer. Further provided are cells that produce the antibodies, polynucleotides encoding the heavy and/or light chain variable region of the antibodies, and vectors comprising the polynucleotides encoding the heavy and/or light chain variable region of the antibodies.
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