- 专利标题： METHODS OF PRODUCING EPIMERASES AND BENZYLISOQUINOLINE ALKALOIDS
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申请号： EP23167022.5申请日： 2016-05-09
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公开(公告)号： EP4253525A2公开(公告)日： 2023-10-04
- 发明人: SMOLKE, Christina, D. , GALANIE, Stephanie , TRENCHARD, Isis , THODEY, Catherine , LI, Yanran
- 申请人： The Board of Trustees of the Leland Stanford Junior University
- 申请人地址： US Stanford, CA 94305-2038 Office of the General Counsel Building 170, Third Floor, Main Quad P.O. Box 20386
- 代理机构： Carpmaels & Ransford LLP
- 优先权： US201562174475 P 20150611
- 主分类号： C12N1/19
- IPC分类号： C12N1/19 ; C12N15/52 ; C12N15/53
摘要：
A method of epimerizing an (S) -1-benzylisoquinoline alkaloid to an (R) -1-benzylisoquinoline alkaloid is provided. The method comprises contacting the (S) -1-benzylisoquinoline alkaloid with at least one enzyme. Contacting the (S) -1-benzylisoquinoline alkaloid with the at least one enzyme converts the (S) -1-benzylisoquinoline alkaloid to an (R) -1-benzylisoquinoline alkaloid.
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