- 专利标题: CONDENSED IMIDAZOLE COMPOUND
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申请号: JP29938994申请日: 1994-12-02
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公开(公告)号: JPH07224059A公开(公告)日: 1995-08-22
- 发明人: MIYAKE KAZUTOSHI , MATSUKURA MASAYUKI , HIROSHIMA OSAMU , MORI NOBUYUKI , ISHIHARA HIROKI , MUSHA TAKASHI , HAMANO SUKEYUKI
- 申请人: EISAI CO LTD
- 专利权人: EISAI CO LTD
- 当前专利权人: EISAI CO LTD
- 优先权: JP25176189 1989-09-29; JP33664089 1989-12-27
- 主分类号: C07D235/08
- IPC分类号: C07D235/08 ; A61K31/00 ; A61K31/415 ; A61K31/4184 ; A61K31/435 ; A61K31/44 ; A61K31/496 ; A61K31/505 ; A61P9/00 ; A61P9/12 ; A61P43/00 ; C07D221/02 ; C07D235/02 ; C07D235/06 ; C07D235/10 ; C07D235/12 ; C07D235/26 ; C07D235/28 ; C07D403/10 ; C07D471/04 ; C07D487/04
摘要:
PURPOSE:To obtain a new biphenylmethane derivative useful as an agent for the treatment of hypertension and/or cardiac insufficiency and its pharmacologically permissible salt. CONSTITUTION:This biphenylmethane derivative is a compound expressed by formula I [R is H, an alkyl, a cycloalkyl, a halogenated alkyl, S-R (R is H, an alkyl, a cycloalkyl, etc.), etc.; R and R each is H, a halogen, a lower alkyl, etc.; R is H or a lower alkyl; R is group of formula II, carboxyl, etc.; R is H, a halogen, hydroxy or a lower alkoxy; A =A --A =A is CH=CH-CH =CH, etc.] or its pharmacologically permissible salt, e.g. 7-methyl-2-eta- propyl-3-[(2'-(1H-tetrazol-5-yl)-biphenyl-4-yl)methyl]-3H-imidazo[4,5- b]pyridine. The compound of formula I wherein R is group of formula II can be produced by using a compound of formula III as a starting substance, reacting with a nitrile compound and reacting the reaction product with an azide of formula IV.
公开/授权文献
- JP2925962B2 公开/授权日:1999-07-28
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