Invention Grant
- Patent Title: Antibodies directed to IL-17A/IL-17F heterodimers
-
Application No.: US14491641Application Date: 2014-09-19
-
Publication No.: US10011654B2Publication Date: 2018-07-03
- Inventor: David P. Arnott , Austin L. Gurney , Philip E. Hass , James M. Lee , Yan Wu
- Applicant: GENENTECH, INC.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Morrison & Foerster LLP
- Main IPC: A61K39/395
- IPC: A61K39/395 ; C07K16/24 ; C07K14/54 ; G01N33/68

Abstract:
The present invention is directed to a novel naturally occurring human cytokine that is comprised of a heterodimer of interleukin-17 and interleukin-17F designated herein as interleukin 17A/F (IL-17A/F). Also provided herein are vectors and host cells comprising those nucleic acid sequences, chimeric polypeptide molecules comprising the polypeptides of the present invention fused to heterologous polypeptide sequences, specific antibodies which bind to the polypeptides of the present invention and to methods for producing the polypeptides of the present invention. Further provided herein are methods for treating degenerative cartilaginous disorders and other inflammatory diseases.
Public/Granted literature
- US20150232551A1 ANTIBODIES DIRECTED TO IL-17A/F HETEROLOGOUS POLYPEPTIDES AND THERAPEUTIC USES OF THEREOF Public/Granted day:2015-08-20
Information query