- 专利标题： Functionally switchable self-assembled coating compound for controlling translocation of molecule through nanopores
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申请号： US13439265申请日： 2012-04-04
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公开(公告)号： US10029915B2公开(公告)日： 2018-07-24
- 发明人: Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
- 申请人： Ali Afzali-Ardakani , Stefan Harrer , Binquan Luan , Hongbo Peng , Gustavo A. Stolovitzky , Deqiang Wang
- 申请人地址： US NY Armonk
- 专利权人： INTERNATIONAL BUSINESS MACHINES CORPORATION
- 当前专利权人： INTERNATIONAL BUSINESS MACHINES CORPORATION
- 当前专利权人地址： US NY Armonk
- 代理机构： Cantor Colburn LLP
- 代理商 Vazken Alexanian
- 主分类号： G01N27/40
- IPC分类号： G01N27/40 ; B82Y30/00 ; B82Y40/00 ; F03B11/02 ; B82Y15/00 ; G01N27/00
摘要：
A technique for a nanodevice is provided. The nanodevice includes a fluidic cell, and a membrane dividing the fluidic cell. A nanopore is formed through the membrane, and the nanopore is coated with an organic compound. A first part of the organic compound binds to a surface of the nanopore and a second part of the organic compound is exposed freely inside of the nanopore. The second part of the organic compound is configured to be switched among a first neutral hydrophilic end group, a second negatively charged hydrophilic end group, and a third neutral hydrophobic end group based on a switching mechanism.