- Patent Title: Pyrrolobenzodiazepine antibody drug conjugates and methods of use
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Application No.: US15281830Application Date: 2016-09-30
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Publication No.: US10058613B2Publication Date: 2018-08-28
- Inventor: Peter Dragovich , Thomas Pillow , Jack Sadowsky , Mark X. Sliwkowski , BinQing Wei
- Applicant: Genentech, Inc.
- Applicant Address: US CA South San Francisco
- Assignee: Genentech, Inc.
- Current Assignee: Genentech, Inc.
- Current Assignee Address: US CA South San Francisco
- Agency: Viksnins Harris Padys Malen LLP
- Main IPC: C07K16/00
- IPC: C07K16/00 ; A61K45/06 ; C07K16/28 ; C07D519/00 ; C07K16/32 ; A61K31/5517 ; A61K47/68
Abstract:
The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.
Public/Granted literature
- US20170095570A1 PYRROLOBENZODIAZEPINE ANTIBODY DRUG CONJUGATES AND METHODS OF USE Public/Granted day:2017-04-06
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