公开(公告)号：US20250161315A1

公开(公告)日：2025-05-22

申请号：US19029035

申请日：2025-01-17

Applicant: Genentech, Inc.

Inventor： Mark X. Sliwkowski ,  Scott Holden ,  Stuart Lutzker ,  Jay Tibbitts ,  Nelson L. Jumbe

IPC: A61K31/5365 ,  A61K9/00 ,  A61K31/337 ,  A61K31/416 ,  A61K31/513 ,  A61K31/517 ,  A61K31/5355 ,  A61K31/5377 ,  A61K31/555 ,  A61K39/00 ,  A61K39/395 ,  A61K45/06 ,  A61K47/68 ,  C07K16/32 ,  G01N33/50 ,  G01N33/574

Abstract: Combinations of the antibody-drug conjugate trastuzumab-MCC-DM1 and chemotherapeutic agents, including stereoisomers, geometric isomers, tautomers, solvates, metabolites and pharmaceutically acceptable salts thereof, are useful for inhibiting tumor cell growth, and for treating disorders such as cancer mediated by HER2 and KDR (VEGFR receptor 1). Methods of using such combinations for in vitro, in situ, and in vivo diagnosis, prevention or treatment of such disorders in mammalian cells, or associated pathological conditions, are disclosed.

公开(公告)号：US20180185486A1

公开(公告)日：2018-07-05

申请号：US15899612

申请日：2018-02-20

Applicant: Genentech, Inc.

Inventor： Peter Dragovich ,  Thomas Pillow ,  Jack Sadowsky ,  Mark X. Sliwkowski ,  BinQing Wei

IPC: A61K45/06 ,  C07D519/00 ,  A61K47/68 ,  C07K16/32 ,  C07K16/28 ,  A61K31/5517

CPC classification number: A61K45/06 ,  A61K31/5517 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  C07D519/00 ,  C07K16/2803 ,  C07K16/32 ,  C07K2317/40 ,  C07K2317/522 ,  C07K2317/567

Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.

公开(公告)号：US09518118B2

公开(公告)日：2016-12-13

申请号：US14851001

申请日：2015-09-11

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/28 ,  A61K47/48 ,  C07K16/32 ,  A61K39/395 ,  G01N33/574

CPC classification number: C07K16/32 ,  A61K31/5517 ,  A61K31/675 ,  A61K31/704 ,  A61K39/3955 ,  A61K47/68 ,  A61K47/6809 ,  A61K47/6849 ,  A61K47/6855 ,  A61K47/6863 ,  A61K49/00 ,  C07K16/2863 ,  C07K16/3015 ,  C07K2317/24 ,  C07K2317/34 ,  C07K2317/51 ,  C07K2317/515 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/92 ,  G01N33/57415 ,  G01N33/57446 ,  G01N33/57492 ,  G01N2333/82

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

Abstract translation: 本发明提供抗HER2抗体和免疫缀合物及其使用方法。

公开(公告)号：US20140193414A1

公开(公告)日：2014-07-10

申请号：US14100211

申请日：2013-12-09

Applicant: Genentech, Inc.

Inventor： Germaine Fuh ,  Lauric Haber ,  Gabriele Schaefer ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  C07K16/28 ,  A61K47/48

CPC classification number: C07K16/28 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92

Abstract: The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.

公开(公告)号：US20230041134A1

公开(公告)日：2023-02-09

申请号：US17720717

申请日：2022-04-14

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  A61K47/68 ,  A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61K31/5517 ,  A61K31/675 ,  A61K31/704 ,  A61K49/00 ,  C07K16/30

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20190177429A1

公开(公告)日：2019-06-13

申请号：US16170819

申请日：2018-10-25

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  G01N33/574 ,  A61K49/00 ,  A61K39/395 ,  A61K31/704 ,  A61K31/675 ,  A61K31/5517 ,  C07K16/30 ,  A61K47/68 ,  C07K16/28

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US10058613B2

公开(公告)日：2018-08-28

申请号：US15281830

申请日：2016-09-30

Applicant: Genentech, Inc.

Inventor： Peter Dragovich ,  Thomas Pillow ,  Jack Sadowsky ,  Mark X. Sliwkowski ,  BinQing Wei

IPC: C07K16/00 ,  A61K45/06 ,  C07K16/28 ,  C07D519/00 ,  C07K16/32 ,  A61K31/5517 ,  A61K47/68

CPC classification number: A61K45/06 ,  A61K31/5517 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  C07D519/00 ,  C07K16/2803 ,  C07K16/32 ,  C07K2317/40 ,  C07K2317/522 ,  C07K2317/567

Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.

公开(公告)号：US09327035B2

公开(公告)日：2016-05-03

申请号：US14066258

申请日：2013-10-29

Applicant: Genentech, Inc.

Inventor： Germaine Fuh ,  Lauric Haber ,  Gabriele Schaefer ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  A61K47/48 ,  C07K16/28 ,  A61K39/00

CPC classification number: A61K47/48569 ,  A61K2039/505 ,  A61K2039/507 ,  C07K16/28 ,  C07K16/2863 ,  C07K16/32 ,  C07K2317/31 ,  C07K2317/56 ,  C07K2317/565 ,  C07K2317/73 ,  C07K2317/732 ,  C07K2317/92

Abstract: The invention provides anti-HER antibodies, including multispecific anti-HER antibodies, compositions comprising and methods of using these antibodies. Also provided herein are EGFR/HER3 multispecific antibodies that are less toxic than traditional EGFR antagonists.

Abstract translation: 本发明提供抗HER抗体，包括多特异性抗HER抗体，组合物和使用这些抗体的方法。 本文还提供了比传统EGFR拮抗剂毒性小的EGFR / HER3多特异性抗体。

公开(公告)号：US10179820B2

公开(公告)日：2019-01-15

申请号：US15296454

申请日：2016-10-18

Applicant: Genentech, Inc.

Inventor： Xiaocheng Chen ,  Mark Dennis ,  Jagath Reddy Junutula ,  Gail Lewis Phillips ,  Thomas Harden Pillow ,  Mark X. Sliwkowski

IPC: C07K16/32 ,  A61K39/395 ,  C07K16/28 ,  G01N33/574 ,  A61K31/5517 ,  A61K31/675 ,  A61K31/704 ,  A61K49/00 ,  C07K16/30 ,  A61K47/68

Abstract: The invention provides anti-HER2 antibodies and immunoconjugates and methods of using the same.

公开(公告)号：US20180326062A1

公开(公告)日：2018-11-15

申请号：US16036575

申请日：2018-07-16

Applicant: Genentech, Inc.

Inventor： Peter Dragovich ,  Thomas Pillow ,  Jack Sadowsky ,  Mark X. Sliwkowski ,  BinQing Wei

IPC: A61K45/06 ,  A61K47/68 ,  A61K31/5517 ,  C07K16/32 ,  C07D519/00 ,  C07K16/28

CPC classification number: A61K45/06 ,  A61K31/5517 ,  A61K47/6803 ,  A61K47/6851 ,  A61K47/6855 ,  A61K47/6889 ,  C07D519/00 ,  C07K16/2803 ,  C07K16/32 ,  C07K2317/40 ,  C07K2317/522 ,  C07K2317/567

Abstract: The invention provides antibody-drug conjugates comprising an antibody conjugated to a pyrrolobenzodiazepine drug moiety via a disulfide linker, pyrrolobenzodiazepine linker-drug intermediates, and methods of using the antibody-drug conjugates.