Invention Grant
- Patent Title: Functionalized 4- and 5-vinyl substituted regioisomers of 1, 2, 3-triazoles via 1, 3-dipolar cycloaddition and polymers thereof
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Application No.: US14960597Application Date: 2015-12-07
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Publication No.: US10093633B2Publication Date: 2018-10-09
- Inventor: Osama M. Musa , Brian Marr
- Applicant: ISP Investments LLC
- Applicant Address: US DE Wilmington
- Assignee: ISP Investments LLC
- Current Assignee: ISP Investments LLC
- Current Assignee Address: US DE Wilmington
- Agent William J. Davis
- Main IPC: C07D403/00
- IPC: C07D403/00 ; C07D249/04 ; A01N43/647 ; C07D295/155 ; C08F26/06 ; A61K8/49 ; A61Q19/00 ; C09D139/04 ; C09J139/04 ; C11D3/28 ; A61K8/81 ; C11D3/37

Abstract:
The present invention provides novel functionalized mixtures 4- and 5-vinyl substituted regioisomers of 1,2,3-triazoles via 1,3-dipolar cycloaddition. Functionalized alkyne moieties with a terminal alcoholic functionality are reacted with functionalized organic moieties with a terminal leaving group and an azide to provide an alcoholic functionalized mixture of 4- and 5-substituted regioisomers of 1,2,3-triazole moieties. The mixture may be converted to a wide variety of useful functionalized mixtures of 4- and 5-vinyl substituted regioisomers of 1,2,3-triazole moieties, which in turn can be converted to a wide variety of useful polymers The novel alcoholic functionalized mixtures of 4- and 5-substituted regioisomers can be separated by chromatography to provide the purified 4- and 5-alcoholic functionalized substituted 1,2,3-triazole moieties. The novel compounds of the invention can be employed in a wide variety of compositions (Formulae (I), (II)); wherein R1, R2, R3, and R4, are defined herein.
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