公开(公告)号：US10093633B2

公开(公告)日：2018-10-09

申请号：US14960597

申请日：2015-12-07

Applicant: ISP Investments LLC

Inventor： Osama M. Musa ,  Brian Marr

IPC: C07D403/00 ,  C07D249/04 ,  A01N43/647 ,  C07D295/155 ,  C08F26/06 ,  A61K8/49 ,  A61Q19/00 ,  C09D139/04 ,  C09J139/04 ,  C11D3/28 ,  A61K8/81 ,  C11D3/37

Abstract: The present invention provides novel functionalized mixtures 4- and 5-vinyl substituted regioisomers of 1,2,3-triazoles via 1,3-dipolar cycloaddition. Functionalized alkyne moieties with a terminal alcoholic functionality are reacted with functionalized organic moieties with a terminal leaving group and an azide to provide an alcoholic functionalized mixture of 4- and 5-substituted regioisomers of 1,2,3-triazole moieties. The mixture may be converted to a wide variety of useful functionalized mixtures of 4- and 5-vinyl substituted regioisomers of 1,2,3-triazole moieties, which in turn can be converted to a wide variety of useful polymers The novel alcoholic functionalized mixtures of 4- and 5-substituted regioisomers can be separated by chromatography to provide the purified 4- and 5-alcoholic functionalized substituted 1,2,3-triazole moieties. The novel compounds of the invention can be employed in a wide variety of compositions (Formulae (I), (II)); wherein R1, R2, R3, and R4, are defined herein.