Disclosed is a water-proof and dust-proof membrane assembly and applications thereof. The water-proof and dust-proof membrane assembly comprises a body and a supporting member. The body is of membrane and has a first surface, a second surface, and an asymmetric porous structure formed between the first surface and the second surface of the body. The asymmetric porous structure has a thickness ranging between 1 μm and 1000 μm, a first volumetric porosity ranging between 5% and 99%. The asymmetric porous structure has plural pores, and each pore has a pore diameter between 0.01 μm and 15 μm. The supporting member is of a polymeric material and has a first contacting surface, a second contacting surface, and a second volumetric porosity which is greater than the first volumetric porosity. The first contacting surface of the supporting member is adhered to the first surface of the body.