Processing an adaptive interrupt includes selectively setting an input/output (I/O) device in a computing system to an adaptive masking mode when at least one factor value of the at least one I/O device regarding a workload of the computing system exceeds a first threshold condition. Processing the adaptive interrupt further includes performing an interrupt masking process, where an interrupts generated by an I/O device set to the adaptive masking mode are prevented from being output when a time interval between I/O submission events of the I/O device is less than a first threshold value. The adaptive interrupt may be processed by an adaptive interrupt processing module (AIPM). The AIPM may be included in various portions of the computing system, including the I/O device and a host connected to the I/O device.