Invention Grant
- Patent Title: Cyclic di-nucleotide compounds as sting agonists
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Application No.: US15234182Application Date: 2016-08-11
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Publication No.: US10106574B2Publication Date: 2018-10-23
- Inventor: Michael D. Altman , Wonsuk Chang , Jared N. Cumming , Rui Liang , Jongwon Lim , Tony Siu , Benjamin Wesley Trotter , Quang T. Truong , Shawn P. Walsh
- Applicant: Merck Sharp & Dohme Corp.
- Applicant Address: US NJ Rahway
- Assignee: Merck Sharp & Dohme Corp.
- Current Assignee: Merck Sharp & Dohme Corp.
- Current Assignee Address: US NJ Rahway
- Agent Julie M. Lake; Catherine A. Fitch
- Main IPC: A61K31/70
- IPC: A61K31/70 ; A01N43/04 ; C07H21/04 ; C07H21/02 ; A61K39/39 ; C07H19/20 ; C07H19/23 ; C07H21/00 ; A61K31/7064 ; A61K31/7084 ; A61K31/708 ; A61K31/706 ; A61K31/7076
Abstract:
A class of polycyclic compounds of general formula (I), of general formula (I′), or of general formula (I″), wherein Base1, Base2, Y, Ya, Xa, Xa1, Xb, Xb1, Xc, Xc1, Xd, Xd1, R1, R1a, R2, R2a, R3, R4, R4a, R5, R6, R6a, R7, R7a, R8, and R8a are defined herein, that may be useful as inductors of type I interferon production, specifically as STING active agents, are provided. Also provided are processes for the synthesis and use of compounds.
Public/Granted literature
- US20170044206A1 CYCLIC DI-NUCLEOTIDE COMPOUNDS AS STING AGONISTS Public/Granted day:2017-02-16
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