Invention Grant
- Patent Title: Glycosphingolipids for use in modulating immune responses
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Application No.: US14376747Application Date: 2013-02-07
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Publication No.: US10227290B2Publication Date: 2019-03-12
- Inventor: Michael A. Fischbach , Jeffrey A. Bluestone , Cristina Penaranda , Laura Brown , Jon Clardy
- Applicant: The Regents of the University of California , President and Fellows of Harvard College
- Applicant Address: US CA Oakland US MA Cambridge
- Assignee: The Regents of the University of California,President and Fellows of Harvard College
- Current Assignee: The Regents of the University of California,President and Fellows of Harvard College
- Current Assignee Address: US CA Oakland US MA Cambridge
- Agency: Seed IP Law Group LLP
- International Application: PCT/US2013/025205 WO 20130207
- International Announcement: WO2013/119857 WO 20130815
- Main IPC: A61K35/12
- IPC: A61K35/12 ; A61K35/26 ; C07H15/04 ; C07H15/06 ; C12P13/02 ; C12P19/44 ; C07C235/08 ; C07F9/141
Abstract:
Provided herein are sphingolipid compounds that are useful for activating natural killer T cells. Also provided are methods for treating or preventing a disease or disorder that is treatable by activating the immune system by stimulating natural killer T cells. The compounds are therefore useful for treating or reducing the likelihood of occurrence of an immune diseases and disorders, such as autoimmune diseases or disorders. The compounds may also be used for treating or reducing the likelihood of occurrence of a microbial infection or for treating or reducing the likelihood of occurrence of a cancer in a subject by administering the sphingolipid compounds described herein.
Public/Granted literature
- US20140377291A1 GLYCOSPHINGOLIPIDS FOR USE IN MODULATING IMMUNE RESPONSES Public/Granted day:2014-12-25
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