Invention Grant
- Patent Title: Isoquiniline and napthalene-substituted compounds as mGluR4 allosteric potentiators, compositions, and methods of treating neurological dysfunction
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Application No.: US15547775Application Date: 2016-02-01
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Publication No.: US10227343B2Publication Date: 2019-03-12
- Inventor: P. Jeffrey Conn , Craig W. Lindsley , Colleen M. Niswender , Corey R. Hopkins , Joanne Bronson , Yong-Jin Wu , Kyle Emmitte , Joe Panarese , Darren W. Engers , Julie Engers
- Applicant: Vanderbilt University
- Applicant Address: US TN Nashville
- Assignee: Vanderbilt University
- Current Assignee: Vanderbilt University
- Current Assignee Address: US TN Nashville
- Agency: Stites & Harbison PLLC
- Agent Richard S. Meyers, Jr.
- International Application: PCT/US2016/016012 WO 20160201
- International Announcement: WO2016/123627 WO 20160804
- Main IPC: C07D471/04
- IPC: C07D471/04 ; A61K31/496 ; A61K31/437 ; A61K31/554 ; A61K31/553 ; C07D487/04 ; A61K31/4985 ; A61K31/4725 ; A61K31/541 ; A61K31/4745 ; A61K31/506 ; A61K31/5377 ; A61K31/502 ; C07D401/12 ; A61K31/4375 ; C07D519/00 ; A61K31/519 ; A61K45/06
Abstract:
Compounds which are useful as allosteric potentiators/positive allosteric modulators of the metabotropic glutamate receptor subtype 4 (mGluR4); pharmaceutical compositions comprising the compounds; and methods of using the compounds, for example, in treating neurological and psychiatric disorders or other disease state associated with glutamate dysfunction.
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